Viruses, Volume 13, Issue 2 (February 2021) – 213 articles
Cover Story (view full-size image): Clonal expansion of hepatocytes, a risk factor for the development of hepatocellular carcinoma (HCC), occurs in the liver during chronic hepatitis B virus infection. Hepatocytes are self-renewing, and the emergence of HCC from hepatocytes involves initiation (genetic) and promotion (cell proliferation). Genetic changes are due to random integration of HBV DNA and oxidative DNA damage caused by chronic inflammation. Promotion is due to replacement of hepatocytes killed by the immune response leading to loss of some hepatocyte lineages and expansion of others, including hepatocytes that no longer sustain virus replication. Shown here, as an example, is a focus of woodchuck hepatitis virus (WHV) core antigen-negative hepatocytes in the liver of a woodchuck with chronic WHV infection. View this paper
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