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Article

Genomic Signatures of SARS-CoV-2 Associated with Patient Mortality

1
Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
2
Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA
3
Department of Pathology, School of Medicine, Tulane University, New Orleans, LA 70112, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Luis Martinez-Sobrido and Fernando Almazan Toral
Received: 1 December 2020 / Revised: 12 January 2021 / Accepted: 27 January 2021 / Published: 2 February 2021
(This article belongs to the Collection Coronaviruses)
Infections with SARS-CoV-2 can progress toward multiple clinical outcomes, and the identification of factors associated with disease severity would represent a major advance to guide care and improve prognosis. We tested for associations between SARS-CoV-2 genomic variants from an international cohort of 2508 patients and mortality rates. Findings were validated in a second cohort. Phylogenetic analysis of SARS-CoV-2 genome sequences revealed four well-resolved clades which had significantly different mortality rates, even after adjusting for patient demographic and geographic characteristics. We further identified ten single-nucleotide polymorphisms (SNPs) in the SARS-CoV-2 genome that were associated with patient mortality. Three SNPs remained associated with mortality in a generalized linear model (GLM) that also included patient age, sex, geographic region, and month of sample collection. Multiple SNPs were confirmed in the validation cohort. These SNPs represent targets to assess the mechanisms underlying COVID-19 disease severity and warrant straightforward validation in functional studies. View Full-Text
Keywords: COVID-19; coronavirus; pathogenesis; SNP; genome COVID-19; coronavirus; pathogenesis; SNP; genome
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MDPI and ACS Style

Dumonteil, E.; Fusco, D.; Drouin, A.; Herrera, C. Genomic Signatures of SARS-CoV-2 Associated with Patient Mortality. Viruses 2021, 13, 227. https://0-doi-org.brum.beds.ac.uk/10.3390/v13020227

AMA Style

Dumonteil E, Fusco D, Drouin A, Herrera C. Genomic Signatures of SARS-CoV-2 Associated with Patient Mortality. Viruses. 2021; 13(2):227. https://0-doi-org.brum.beds.ac.uk/10.3390/v13020227

Chicago/Turabian Style

Dumonteil, Eric; Fusco, Dahlene; Drouin, Arnaud; Herrera, Claudia. 2021. "Genomic Signatures of SARS-CoV-2 Associated with Patient Mortality" Viruses 13, no. 2: 227. https://0-doi-org.brum.beds.ac.uk/10.3390/v13020227

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