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Brief Report

Titers of Neutralizing Antibodies against SARS-CoV-2 Are Independent of Symptoms of Non-Severe COVID-19 in Young Adults

1
SPIEZ Laboratory, Austrasse, 3700 Spiez, Switzerland
2
Swiss Armed Forces, Medical Services, Worblentalstrasse, 3063 Ittigen, Switzerland
3
Epidemiology, Biostatistics and Prevention Institute, Travel Clinic, Hirschengraben, University of Zurich, 8006 Zürich, Switzerland
4
Jeffrey Cheah Biomedical Centre, Department of Haematology and MRC—Wellcome Stem Cell Institute, Puddicombe Way, University of Cambridge, Cambridge CB2 AW, UK
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Luis Martinez-Sorbido and Fernando Almazan Toral
Received: 22 January 2021 / Revised: 8 February 2021 / Accepted: 8 February 2021 / Published: 12 February 2021
(This article belongs to the Collection Coronaviruses)
Neutralizing antibodies are an important part of the humoral immune response to SARS-CoV-2. It is currently unclear to what extent such antibodies are produced after non-severe disease or asymptomatic infection. We studied a cluster of SARS-CoV-2 infections among a homogeneous population of 332 predominantly male Swiss soldiers and determined the neutralizing antibody response with a serum neutralization assay using a recombinant SARS-CoV-2-GFP. All patients with non-severe COVID-19 showed a swift humoral response within two weeks after the onset of symptoms, which remained stable for the duration of the study. One month after the outbreak, titers in COVID-19 convalescents did not differ from the titers of asymptomatically infected individuals. Furthermore, symptoms of COVID-19 did not correlate with neutralizing antibody titers. Therefore, we conclude that asymptomatic infection can induce the same humoral immunity as non-severe COVID-19 in young adults. View Full-Text
Keywords: SNT; virus neutralization test; ELISA; young adults; SARS-CoV-2; COVID-19 SNT; virus neutralization test; ELISA; young adults; SARS-CoV-2; COVID-19
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MDPI and ACS Style

Jonsdottir, H.R.; Bielecki, M.; Siegrist, D.; Buehrer, T.W.; Züst, R.; Deuel, J.W. Titers of Neutralizing Antibodies against SARS-CoV-2 Are Independent of Symptoms of Non-Severe COVID-19 in Young Adults. Viruses 2021, 13, 284. https://0-doi-org.brum.beds.ac.uk/10.3390/v13020284

AMA Style

Jonsdottir HR, Bielecki M, Siegrist D, Buehrer TW, Züst R, Deuel JW. Titers of Neutralizing Antibodies against SARS-CoV-2 Are Independent of Symptoms of Non-Severe COVID-19 in Young Adults. Viruses. 2021; 13(2):284. https://0-doi-org.brum.beds.ac.uk/10.3390/v13020284

Chicago/Turabian Style

Jonsdottir, Hulda R.; Bielecki, Michel; Siegrist, Denise; Buehrer, Thomas W.; Züst, Roland; Deuel, Jeremy W. 2021. "Titers of Neutralizing Antibodies against SARS-CoV-2 Are Independent of Symptoms of Non-Severe COVID-19 in Young Adults" Viruses 13, no. 2: 284. https://0-doi-org.brum.beds.ac.uk/10.3390/v13020284

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