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Communication

Antibody Response to the BNT162b2 mRNA COVID-19 Vaccine in Subjects with Prior SARS-CoV-2 Infection

1
Department of Infectious—Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, I-37024 Negrar, Italy
2
Department of Molecular Medicine, University of Padova, I-35121 Padova, Italy
3
Microbiology and Virology Unit, Padova University Hospital, I-35128 Padova, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Gilda Tachedjian
Received: 16 February 2021 / Revised: 28 February 2021 / Accepted: 3 March 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Pre-existing Immunity Effects on Viral Infections and Vaccinations)
Although antibody levels progressively decrease following SARS-CoV-2 infection, the immune memory persists for months. Thus, individuals who naturally contracted SARS-CoV-2 are expected to develop a more rapid and sustained response to COVID-19 vaccines than naïve individuals. In this study, we analyzed the dynamics of the antibody response to the BNT162b2 mRNA COVID-19 vaccine in six healthcare workers who contracted SARS-CoV-2 in March 2020, in comparison to nine control subjects without a previous infection. The vaccine was well tolerated by both groups, with no significant difference in the frequency of vaccine-associated side effects, with the exception of local pain, which was more common in previously infected subjects. Overall, the titers of neutralizing antibodies were markedly higher in response to the vaccine than after natural infection. In all subjects with pre-existing immunity, a rapid increase in anti-spike receptor-binding domain (RBD) IgG antibodies and neutralizing antibody titers was observed one week after the first dose, which seemed to act as a booster. Notably, in previously infected individuals, neutralizing antibody titers 7 days after the first vaccine dose were not significantly different from those observed in naïve subjects 7 days after the second vaccine dose. These results suggest that, in previously infected people, a single dose of the vaccine might be sufficient to induce an effective response. View Full-Text
Keywords: COVID-19 vaccine; neutralizing antibody; anti-spike RBD IgG antibody; BNT162b2 vaccine; SARS-CoV-2; immune response; vaccination; immunogenicity; reactogenicity; vaccine doses COVID-19 vaccine; neutralizing antibody; anti-spike RBD IgG antibody; BNT162b2 vaccine; SARS-CoV-2; immune response; vaccination; immunogenicity; reactogenicity; vaccine doses
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MDPI and ACS Style

Gobbi, F.; Buonfrate, D.; Moro, L.; Rodari, P.; Piubelli, C.; Caldrer, S.; Riccetti, S.; Sinigaglia, A.; Barzon, L. Antibody Response to the BNT162b2 mRNA COVID-19 Vaccine in Subjects with Prior SARS-CoV-2 Infection. Viruses 2021, 13, 422. https://0-doi-org.brum.beds.ac.uk/10.3390/v13030422

AMA Style

Gobbi F, Buonfrate D, Moro L, Rodari P, Piubelli C, Caldrer S, Riccetti S, Sinigaglia A, Barzon L. Antibody Response to the BNT162b2 mRNA COVID-19 Vaccine in Subjects with Prior SARS-CoV-2 Infection. Viruses. 2021; 13(3):422. https://0-doi-org.brum.beds.ac.uk/10.3390/v13030422

Chicago/Turabian Style

Gobbi, Federico; Buonfrate, Dora; Moro, Lucia; Rodari, Paola; Piubelli, Chiara; Caldrer, Sara; Riccetti, Silvia; Sinigaglia, Alessandro; Barzon, Luisa. 2021. "Antibody Response to the BNT162b2 mRNA COVID-19 Vaccine in Subjects with Prior SARS-CoV-2 Infection" Viruses 13, no. 3: 422. https://0-doi-org.brum.beds.ac.uk/10.3390/v13030422

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