Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States

Otto, William R.; Lamson, Daryl M.; Gonzalez, Gabriel; Weinberg, Geoffrey A.; Pecora, Nicole D.; Fisher, Brian T.; St. George, Kirsten; Kajon, Adriana E.

doi:10.3390/v13061105

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Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States

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Division of Infectious Diseases, Department of Pediatrics, The Children’s Hospital of Philadelphia (CHOP), Philadelphia, PA 19104, USA

Center for Pediatric Clinical Effectiveness, CHOP, Philadelphia, PA 19104, USA

Wadsworth Center, New York State Department of Health (WC-NYSDOH), Albany, NY 12201, USA

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National Virus Reference Laboratory (NVRL), University College Dublin, D04 V1W8 Dublin, Ireland

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International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan

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Department of Pediatrics, University of Rochester School of Medicine & Dentistry Rochester (UoR), Rochester, NY 14642, USA

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Department of Pathology and Laboratory Medicine, UoR, Rochester, NY 14642, USA

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Immune Dysregulation Program, CHOP, Philadelphia, PA 19104, USA

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Department of Biomedical Science, University at Albany, SUNY, Albany, NY 12222, USA

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Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA

Author to whom correspondence should be addressed.

Academic Editors: Annasara Lenman and Niklas Arnberg

Viruses 2021, 13(6), 1105; https://0-doi-org.brum.beds.ac.uk/10.3390/v13061105

Received: 9 May 2021 / Revised: 1 June 2021 / Accepted: 5 June 2021 / Published: 9 June 2021

(This article belongs to the Special Issue Adenovirus Pathogenesis)

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Abstract

Background: Human adenovirus (HAdV)-D56 was first described in 2011 by genomics analysis of a strain isolated in France in 2008 from a fatal case of neonatal infection. Since then, it has been reported in cases of keratoconjunctivitis and male urethritis. Three epidemiologically unrelated fatal cases of neonatal sepsis associated with infection by HAdV-D strains with a similar genetic makeup were documented in the United States between 2014 and 2020. Methods: Whole genome sequences were obtained for the isolated strains, and genomics analyses were conducted to compare them to phylogenetically related HAdV-D genomic sequences available in GenBank. Results: The three new US strains were indistinguishable by in silico restriction enzyme analysis. Their genome sequences were 99.9% identical to one another and to the prototype strain isolated in 2008 from a similar context of disease. The phylogenetic reconstruction revealed a highly supported clustering of all HAdV-D56 strains isolated in various countries since 1982. Our comparison to serologically intermediate strains 15/H9 described in the literature indicated that HAdV-D56-like viruses have circulated worldwide since the late 1950s. Conclusion: As with other HAdV-D genotypes with the ability to infect ocular and genital mucosae, the risk of severe prenatal or perinatal HAdV-D56 infection must be considered. View Full-Text

Keywords: adenovirus; neonatal sepsis; genomics; intermediate strain; species HAdV-D

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MDPI and ACS Style

Otto, W.R.; Lamson, D.M.; Gonzalez, G.; Weinberg, G.A.; Pecora, N.D.; Fisher, B.T.; St. George, K.; Kajon, A.E. Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States. Viruses 2021, 13, 1105. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061105

AMA Style

Otto WR, Lamson DM, Gonzalez G, Weinberg GA, Pecora ND, Fisher BT, St. George K, Kajon AE. Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States. Viruses. 2021; 13(6):1105. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061105

Chicago/Turabian Style

Otto, William R., Daryl M. Lamson, Gabriel Gonzalez, Geoffrey A. Weinberg, Nicole D. Pecora, Brian T. Fisher, Kirsten St. George, and Adriana E. Kajon 2021. "Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States" Viruses 13, no. 6: 1105. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061105

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Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States

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