Next Article in Journal
The Viral Capsid: A Master Key to Access the Host Nucleus
Next Article in Special Issue
Hantavirus Research in Finland: Highlights and Perspectives
Previous Article in Journal
Genetic Diversity and Epidemiological Significance of Wild Boar HEV-3 Strains Circulating in Poland
Previous Article in Special Issue
Central Nervous System and Ocular Manifestations in Puumala Hantavirus Infection
Article

The Clinical Presentation of Puumala Hantavirus Induced Hemorrhagic Fever with Renal Syndrome Is Related to Plasma Glucose Concentration

1
Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland
2
Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland
3
Faculty of Social Sciences, Tampere University, 33520 Tampere, Finland
4
Department of Virology, Medicum, University of Helsinki, 00290 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Artur Summerfield
Received: 11 May 2021 / Revised: 10 June 2021 / Accepted: 15 June 2021 / Published: 20 June 2021
(This article belongs to the Special Issue Hantavirus Research in Finland)
Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome characterized by thrombocytopenia, increased capillary leakage, and acute kidney injury (AKI). As glucosuria at hospital admission predicts the severity of PUUV infection, we explored how plasma glucose concentration associates with disease severity. Plasma glucose values were measured during hospital care in 185 patients with PUUV infection. They were divided into two groups according to maximum plasma glucose concentration: P-Gluc < 7.8 mmol/L (n = 134) and P-Gluc ≥ 7.8 mmol/L (n = 51). The determinants of disease severity were analyzed across groups. Patients with P-Gluc ≥7.8 mmol/L had higher hematocrit (0.46 vs. 0.43; p < 0.001) and lower plasma albumin concentration (24 vs. 29 g/L; p < 0.001) than patients with P-Gluc < 7.8 mmol/L. They presented with higher prevalence of pulmonary infiltrations and pleural effusion in chest radiograph, higher prevalence of shock and greater weight change during hospitalization. Patients with P-Gluc ≥ 7.8 mmol/L were characterized by lower platelet count (50 vs. 66 × 109/L; p = 0.001), more severe AKI (plasma creatinine 272 vs. 151 µmol/L; p = 0.001), and longer hospital treatment (8 vs. 6 days; p < 0.001) than patients with P-Gluc < 7.8 mmol/L. Plasma glucose level is associated with the severity of capillary leakage, thrombocytopenia, inflammation, and AKI in patients with acute PUUV infection. View Full-Text
Keywords: puumala hantavirus; hyperglycemia; capillary leakage; thrombocytopenia; AKI; endothelial damage puumala hantavirus; hyperglycemia; capillary leakage; thrombocytopenia; AKI; endothelial damage
Show Figures

Figure 1

MDPI and ACS Style

Tietäväinen, J.; Mäkelä, S.; Huhtala, H.; Pörsti, I.H.; Strandin, T.; Vaheri, A.; Mustonen, J. The Clinical Presentation of Puumala Hantavirus Induced Hemorrhagic Fever with Renal Syndrome Is Related to Plasma Glucose Concentration. Viruses 2021, 13, 1177. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061177

AMA Style

Tietäväinen J, Mäkelä S, Huhtala H, Pörsti IH, Strandin T, Vaheri A, Mustonen J. The Clinical Presentation of Puumala Hantavirus Induced Hemorrhagic Fever with Renal Syndrome Is Related to Plasma Glucose Concentration. Viruses. 2021; 13(6):1177. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061177

Chicago/Turabian Style

Tietäväinen, Johanna, Satu Mäkelä, Heini Huhtala, Ilkka H. Pörsti, Tomas Strandin, Antti Vaheri, and Jukka Mustonen. 2021. "The Clinical Presentation of Puumala Hantavirus Induced Hemorrhagic Fever with Renal Syndrome Is Related to Plasma Glucose Concentration" Viruses 13, no. 6: 1177. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061177

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop