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Review

The Viral Capsid: A Master Key to Access the Host Nucleus

1
Advanced Molecular Virology and Retroviral Dynamics Group, Department of Virology, Pasteur Institute, 75015 Paris, France
2
Immunity and Cancer Department, Curie Institute, PSL Research University, INSERM U932, 75005 Paris, France
*
Author to whom correspondence should be addressed.
Academic Editor: Akira Ono
Received: 2 May 2021 / Revised: 2 June 2021 / Accepted: 16 June 2021 / Published: 20 June 2021
(This article belongs to the Special Issue Cell-Host Interplay for Viral Nuclear Import)
Viruses are pathogens that have evolved to hijack the cellular machinery to replicate themselves and spread to new cells. During the course of evolution, viruses developed different strategies to overcome the cellular defenses and create new progeny. Among them, some RNA and many DNA viruses require access to the nucleus to replicate their genome. In non-dividing cells, viruses can only access the nucleus through the nuclear pore complex (NPC). Therefore, viruses have developed strategies to usurp the nuclear transport machinery and gain access to the nucleus. The majority of these viruses use the capsid to manipulate the nuclear import machinery. However, the particular tactics employed by each virus to reach the host chromatin compartment are very different. Nevertheless, they all require some degree of capsid remodeling. Recent notions on the interplay between the viral capsid and cellular factors shine new light on the quest for the nuclear entry step and for the fate of these viruses. In this review, we describe the main components and function of nuclear transport machinery. Next, we discuss selected examples of RNA and DNA viruses (HBV, HSV, adenovirus, and HIV) that remodel their capsid as part of their strategies to access the nucleus and to replicate. View Full-Text
Keywords: viral nuclear entry; viral replication; host–viral interactions viral nuclear entry; viral replication; host–viral interactions
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MDPI and ACS Style

Blanco-Rodriguez, G.; Di Nunzio, F. The Viral Capsid: A Master Key to Access the Host Nucleus. Viruses 2021, 13, 1178. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061178

AMA Style

Blanco-Rodriguez G, Di Nunzio F. The Viral Capsid: A Master Key to Access the Host Nucleus. Viruses. 2021; 13(6):1178. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061178

Chicago/Turabian Style

Blanco-Rodriguez, Guillermo, and Francesca Di Nunzio. 2021. "The Viral Capsid: A Master Key to Access the Host Nucleus" Viruses 13, no. 6: 1178. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061178

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