Next Article in Journal
SARS-CoV-2 Infection in Dogs and Cats from Southern Germany and Northern Italy during the First Wave of the COVID-19 Pandemic
Next Article in Special Issue
Coagulopathy in Acute Puumala Hantavirus Infection
Previous Article in Journal
Potential Utility of Natural Killer Cells for Eliminating Cells Harboring Reactivated Latent HIV-1 Following the Removal of CD8+ T Cell-Mediated Pro-Latency Effect(s)
Previous Article in Special Issue
The Clinical Presentation of Puumala Hantavirus Induced Hemorrhagic Fever with Renal Syndrome Is Related to Plasma Glucose Concentration

Hantavirus Research in Finland: Highlights and Perspectives

Department of Virology, Medicum, University of Helsinki, 00290 Helsinki, Finland
Wildlife Ecology, Natural Resources Institute Finland, 00790 Helsinki, Finland
Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland
Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland
Author to whom correspondence should be addressed.
Academic Editor: Hironori Sato
Received: 17 May 2021 / Revised: 20 July 2021 / Accepted: 23 July 2021 / Published: 26 July 2021
(This article belongs to the Special Issue Hantavirus Research in Finland)
Finland has the highest incidence of hantavirus infections globally, with a significant impact on public health. The large coverage of boreal forests and the cyclic dynamics of the dominant forest rodent species, the bank vole Myodes glareolus, explain most of this. We review the relationships between Puumala hantavirus (PUUV), its host rodent, and the hantavirus disease, nephropathia epidemica (NE), in Finland. We describe the history of NE and its diagnostic research in Finland, the seasonal and multiannual cyclic dynamics of PUUV in bank voles impacting human epidemiology, and we compare our northern epidemiological patterns with those in temperate Europe. The long survival of PUUV outside the host and the life-long shedding of PUUV by the bank voles are highlighted. In humans, the infection has unique features in pathobiology but rarely long-term consequences. NE is affected by specific host genetics and risk behavior (smoking), and certain biomarkers can predict the outcome. Unlike many other hantaviruses, PUUV causes a relatively mild disease and is rarely fatal. Reinfections do not exist. Antiviral therapy is complicated by the fact that when symptoms appear, the patient already has a generalized infection. Blocking vascular leakage measures counteracting pathobiology, offer a real therapeutic approach. View Full-Text
Keywords: bank vole; ecology; hantavirus; hemorrhagic fever with renal syndrome; nephropathia epidemica; Puumala virus; rodent bank vole; ecology; hantavirus; hemorrhagic fever with renal syndrome; nephropathia epidemica; Puumala virus; rodent
MDPI and ACS Style

Vaheri, A.; Henttonen, H.; Mustonen, J. Hantavirus Research in Finland: Highlights and Perspectives. Viruses 2021, 13, 1452.

AMA Style

Vaheri A, Henttonen H, Mustonen J. Hantavirus Research in Finland: Highlights and Perspectives. Viruses. 2021; 13(8):1452.

Chicago/Turabian Style

Vaheri, Antti, Heikki Henttonen, and Jukka Mustonen. 2021. "Hantavirus Research in Finland: Highlights and Perspectives" Viruses 13, no. 8: 1452.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop