Next Article in Journal
Flavivirus Cell Entry and Membrane Fusion
Next Article in Special Issue
Retroviral Vectors: Post Entry Events and Genomic Alterations
Previous Article in Journal
What Has the Study of the K3 and K5 Viral Ubiquitin E3 Ligases Taught Us about Ubiquitin-Mediated Receptor Regulation?
Review

The Inside Out of Lentiviral Vectors

by 1,2,3,4 and 1,2,3,4,*
1
Department of Human Virology, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France
2
INSERM U758, 46 Allée d’Italie, 69364 Lyon, France
3
University of Lyon 1, 50 Avenue Tony Garnier, 69364 Lyon, France
4
IFR128 BioSciences Lyon-Gerland, Lyon-Biopole, 69364 Lyon, France
*
Author to whom correspondence should be addressed.
Received: 26 November 2010 / Revised: 25 January 2011 / Accepted: 8 February 2011 / Published: 14 February 2011
(This article belongs to the Special Issue Retroviral Vectors)
Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.
Keywords: lentivirus; lentiviral vector; gene therapy; HIV; SIV; EIAV; FIV lentivirus; lentiviral vector; gene therapy; HIV; SIV; EIAV; FIV
MDPI and ACS Style

Durand, S.; Cimarelli, A. The Inside Out of Lentiviral Vectors. Viruses 2011, 3, 132-159. https://0-doi-org.brum.beds.ac.uk/10.3390/v3020132

AMA Style

Durand S, Cimarelli A. The Inside Out of Lentiviral Vectors. Viruses. 2011; 3(2):132-159. https://0-doi-org.brum.beds.ac.uk/10.3390/v3020132

Chicago/Turabian Style

Durand, Stéphanie, and Andrea Cimarelli. 2011. "The Inside Out of Lentiviral Vectors" Viruses 3, no. 2: 132-159. https://0-doi-org.brum.beds.ac.uk/10.3390/v3020132

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop