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Article

Epidermal Delivery of Retinyl Palmitate Loaded Transfersomes: Penetration and Biodistribution Studies

Topical & Oral development R+D Reig Jofre Laboratories, Gran Capitan Street 10, San Joan Despi, 08970 Barcelona, Spain
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Author to whom correspondence should be addressed.
Received: 16 December 2019 / Revised: 24 January 2020 / Accepted: 27 January 2020 / Published: 30 January 2020
(This article belongs to the Special Issue Nano-Micro Encapsulation of Drugs)
The alteration of retinoids levels in the skin can cause different disorders in the maturation of epithelial skin cells. Topical administration of these lipophilic molecules is a challenge that can be addressed by encapsulation into drug delivery systems. In this study, retinyl palmitate transferosomes formulated in cream were developed and the increases in the penetration of the active ingredients as well as the biodistribution were evaluated in vitro and in vivo. Transfersomes demonstrated a significant increase in the administration of retinyl palmitate to the epidermis by quantification of the active ingredients in the different layers of the skin, as well as by fluorescence microscopy of biopsies of non-dermatomized pig-ear skin. These results suggest that transfersomes may be an efficient vehicle for the delivery of retinoids to inner layers of the skin, such as the epidermis. View Full-Text
Keywords: transfersomes; retinyl palmitate; biodistribution; skin; penetration; drug release transfersomes; retinyl palmitate; biodistribution; skin; penetration; drug release
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MDPI and ACS Style

Pena-Rodríguez, E.; Moreno, M.C.; Blanco-Fernandez, B.; González, J.; Fernández-Campos, F. Epidermal Delivery of Retinyl Palmitate Loaded Transfersomes: Penetration and Biodistribution Studies. Pharmaceutics 2020, 12, 112. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics12020112

AMA Style

Pena-Rodríguez E, Moreno MC, Blanco-Fernandez B, González J, Fernández-Campos F. Epidermal Delivery of Retinyl Palmitate Loaded Transfersomes: Penetration and Biodistribution Studies. Pharmaceutics. 2020; 12(2):112. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics12020112

Chicago/Turabian Style

Pena-Rodríguez, Eloy, Mari C. Moreno, Bárbara Blanco-Fernandez, Jordi González, and Francisco Fernández-Campos. 2020. "Epidermal Delivery of Retinyl Palmitate Loaded Transfersomes: Penetration and Biodistribution Studies" Pharmaceutics 12, no. 2: 112. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics12020112

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