Pharmaceutics, Volume 13, Issue 1 (January 2021) – 126 articles
Cover Story (view full-size image): There have been significant advancements in the design, development, and formulation of cocrystals in order to utilize their physicochemical, mechanical, and biopharmaceutical properties. However, manufacturing cocrystal products on an industrial scale continues to remain a challenge. Once the cocrystal is prepared, steps involved in transitioning a cocrystal into a solid dosage form entail numerous unit operations. An undesired consequence of processing is the potential for the cocrystal to amorphize or dissociate into the parent molecules. In an effort to reduce the number of operations, simultaneous formation of cocrystal and granule is a pragmatic methodology in the pharmaceutical industry. View this paper.
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