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Excipients in the Paediatric Population: A Review

Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain
Pharmacotherapy, Pharmacogenetics and Pharmaceutical Technology Research Group Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran via de l’Hospitalet, 199-203, 08090 Barcelona, Spain
Author to whom correspondence should be addressed.
These authors contribute equally to this paper.
Academic Editor: José B. Fariña
Received: 18 February 2021 / Revised: 5 March 2021 / Accepted: 10 March 2021 / Published: 13 March 2021
(This article belongs to the Special Issue Development and Adaptation of New and Better Pediatric Drugs)
This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric medicine formulations, identifying the compounds that scientific literature has marked as potentially harmful regarding the side effects generated after exposure. On the other hand, this review also highlights the importance of carrying out safety -checks on the excipients, which, in most cases, are linked to toxicity studies. An excipient in the compilation of paediatric population databases is expected to target safety and toxicity, as in the STEP database. Finally, a promising pharmaceutical form for child population, ODT (Orally Disintegrating Tablets), will be studied. View Full-Text
Keywords: excipients; paediatrics; security; toxicology; STEP and ODT excipients; paediatrics; security; toxicology; STEP and ODT
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MDPI and ACS Style

Rouaz, K.; Chiclana-Rodríguez, B.; Nardi-Ricart, A.; Suñé-Pou, M.; Mercadé-Frutos, D.; Suñé-Negre, J.M.; Pérez-Lozano, P.; García-Montoya, E. Excipients in the Paediatric Population: A Review. Pharmaceutics 2021, 13, 387.

AMA Style

Rouaz K, Chiclana-Rodríguez B, Nardi-Ricart A, Suñé-Pou M, Mercadé-Frutos D, Suñé-Negre JM, Pérez-Lozano P, García-Montoya E. Excipients in the Paediatric Population: A Review. Pharmaceutics. 2021; 13(3):387.

Chicago/Turabian Style

Rouaz, Khadija, Blanca Chiclana-Rodríguez, Anna Nardi-Ricart, Marc Suñé-Pou, Dèbora Mercadé-Frutos, Josep M. Suñé-Negre, Pilar Pérez-Lozano, and Encarna García-Montoya. 2021. "Excipients in the Paediatric Population: A Review" Pharmaceutics 13, no. 3: 387.

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