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Article

Stability and In Vitro Aerodynamic Studies of Inhalation Powders Containing Ciprofloxacin Hydrochloride Applying Different DPI Capsule Types

Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, 6720 Szeged, Hungary
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Author to whom correspondence should be addressed.
Academic Editors: Alessandra Rossi, Sandra Cvijić, Jelena Djuris and Anne Marie Healy
Received: 21 March 2021 / Revised: 3 May 2021 / Accepted: 6 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Dry Powders for Inhalation: Formulation Design and Quality Assessment)
In the case of capsule-based dry powder inhalation systems (DPIs), the selection of the appropriate capsule is important. The use of gelatin, gelatin-PEG, and HPMC capsules has become widespread in marketed capsule-based DPIs. We aimed to perform a stability test according to the ICH guideline in the above-mentioned three capsule types. The results of the novel combined formulated microcomposite were more favorable than those of the carrier-free formulation for all capsule types. The use of HPMC capsules results in the greatest stability and thus the best in vitro aerodynamic results for both DPI powders after six months. This can be explained by the fact that the residual solvent content (RSC) of the capsules differs. Under the applied conditions the RSC of the HPMC capsule decreased the least and remained within the optimal range, thus becoming less fragmented, which was reflected in the RSC, structure and morphology of the particles, as well as in the in vitro aerodynamic results (there was a difference of approximately 10% in the lung deposition results). During pharmaceutical dosage form developments, emphasis should be placed in the case of DPIs on determining which capsule type will be used for specific formulations. View Full-Text
Keywords: pulmonary drug delivery; powders for inhalation; dry powder inhaler; novel combined formulation; ciprofloxacin hydrochloride, sodium stearate; magnesium stearate; stability test; DPI capsules pulmonary drug delivery; powders for inhalation; dry powder inhaler; novel combined formulation; ciprofloxacin hydrochloride, sodium stearate; magnesium stearate; stability test; DPI capsules
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MDPI and ACS Style

Benke, E.; Varga, P.; Szabó-Révész, P.; Ambrus, R. Stability and In Vitro Aerodynamic Studies of Inhalation Powders Containing Ciprofloxacin Hydrochloride Applying Different DPI Capsule Types. Pharmaceutics 2021, 13, 689. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13050689

AMA Style

Benke E, Varga P, Szabó-Révész P, Ambrus R. Stability and In Vitro Aerodynamic Studies of Inhalation Powders Containing Ciprofloxacin Hydrochloride Applying Different DPI Capsule Types. Pharmaceutics. 2021; 13(5):689. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13050689

Chicago/Turabian Style

Benke, Edit, Patrícia Varga, Piroska Szabó-Révész, and Rita Ambrus. 2021. "Stability and In Vitro Aerodynamic Studies of Inhalation Powders Containing Ciprofloxacin Hydrochloride Applying Different DPI Capsule Types" Pharmaceutics 13, no. 5: 689. https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13050689

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