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Drug Stability Analysis by Raman Spectroscopy

Real-Time Analyzers, Inc., Middletown, CT 06457, USA
Author to whom correspondence should be addressed.
Received: 2 October 2014 / Revised: 15 December 2014 / Accepted: 18 December 2014 / Published: 22 December 2014
Pharmaceutical drugs are available to astronauts to help them overcome the deleterious effects of weightlessness, sickness and injuries. Unfortunately, recent studies have shown that some of the drugs currently used may degrade more rapidly in space, losing their potency before their expiration dates. To complicate matters, the degradation products of some drugs can be toxic. Here, we present a preliminary investigation of the ability of Raman spectroscopy to quantify mixtures of four drugs; acetaminophen, azithromycin, epinephrine, and lidocaine, with their primary degradation products. The Raman spectra for the mixtures were replicated by adding the pure spectra of the drug and its degradant to determine the relative percent contributions using classical least squares. This multivariate approach allowed determining concentrations in ~10 min with a limit of detection of ~4% of the degradant. These results suggest that a Raman analyzer could be used to assess drug potency, nondestructively, at the time of use to ensure crewmember safety. View Full-Text
Keywords: drug stability analysis; drug degradation; Raman spectroscopy; multivariate analysis; astronaut health drug stability analysis; drug degradation; Raman spectroscopy; multivariate analysis; astronaut health
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MDPI and ACS Style

Shende, C.; Smith, W.; Brouillette, C.; Farquharson, S. Drug Stability Analysis by Raman Spectroscopy. Pharmaceutics 2014, 6, 651-662.

AMA Style

Shende C, Smith W, Brouillette C, Farquharson S. Drug Stability Analysis by Raman Spectroscopy. Pharmaceutics. 2014; 6(4):651-662.

Chicago/Turabian Style

Shende, Chetan, Wayne Smith, Carl Brouillette, and Stuart Farquharson. 2014. "Drug Stability Analysis by Raman Spectroscopy" Pharmaceutics 6, no. 4: 651-662.

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