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Volume 10, April

Cardiogenetics, Volume 10, Issue 2 (December 2020) – 4 articles

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Open AccessEditorial
Cardiogenetics: An Open Access Journal
Cardiogenetics 2020, 10(2), 42-44; https://0-doi-org.brum.beds.ac.uk/10.3390/cardiogenetics10020008 - 09 Nov 2020
Viewed by 404
Abstract
“A new era in Cardiogenetics” [...] Full article
Open AccessArticle
Evaluation of the Correlation between the rs4918 Polymorphism of AHSG Gene and Coronary Artery Calcification in Patients with Coronary Artery Disease
Cardiogenetics 2020, 10(2), 33-41; https://0-doi-org.brum.beds.ac.uk/10.3390/cardiogenetics10020007 - 06 Nov 2020
Viewed by 466
Abstract
Objectives: Fetuin-A is a circulating calcification inhibitor that prevents coronary artery calcification (CAC) by increasing calcium phosphate solubility and inhibiting VSMC differentiation and apoptosis. In this study, we investigated the correlation between rs4918 and CAC in patients with coronary artery disease (CAD). Methods: [...] Read more.
Objectives: Fetuin-A is a circulating calcification inhibitor that prevents coronary artery calcification (CAC) by increasing calcium phosphate solubility and inhibiting VSMC differentiation and apoptosis. In this study, we investigated the correlation between rs4918 and CAC in patients with coronary artery disease (CAD). Methods: Forty-two healthy individuals and eighty-one CAD patients were recruited in the present study. The CAC score (CACS) was measured by CT angiography and the genotype analysis of rs4918 single-nucleotide polymorphism SNP was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: The CACS was significantly higher in CAD patients compared to healthy individuals (p < 0.001); however, there was no significant difference between the mean CACS in the presence and absence of rs4918 (p = 0.792). The mean calcium score of the left main coronary artery (LMCA) was significantly lower in carriers of the rs4918 allele (p = 0.036). The frequency of rs4918 SNP was almost similar in the control group and CAD patients (p = 0.846). Conclusions: in patients with CAD, we found no significant association between rs4918 SNP and CACS, indicating that carriers of this allele are not at increased risk of developing cardiovascular diseases compared with those without. Full article
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Open AccessCase Report
Anomalous Left Coronary Artery from the Pulmonary Artery: The Role of Multimodal Imaging—A Case Report
Cardiogenetics 2020, 10(2), 25-32; https://0-doi-org.brum.beds.ac.uk/10.3390/cardiogenetics10020006 - 04 Nov 2020
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Abstract
Anomalous Left Coronary Artery from the Pulmonary Artery (ALCAPA) is a rare coronary artery anomaly which accounts for 0.25–0.5% of all congenital cardiac diseases, where most die within the first year of life. We present a case report of a 50-year-old lady who [...] Read more.
Anomalous Left Coronary Artery from the Pulmonary Artery (ALCAPA) is a rare coronary artery anomaly which accounts for 0.25–0.5% of all congenital cardiac diseases, where most die within the first year of life. We present a case report of a 50-year-old lady who presented to hospital with persistent palpitations. Her admission electrocardiogram found her to be in Atrial Fibrillation (AF). She was rate-controlled and subsequently discharged. Despite that, she represented with further episodes of AF and was referred for an outpatient transthoracic echocardiogram. This revealed a dilated right coronary artery, retrograde flow in the left coronary artery and collateral flow in the myocardium. To investigate, the patient had undergone further imaging which confirmed the diagnosis. As such, she was later shortlisted for surgical intervention. Conclusively, our case exemplifies the role of multimodal imaging to identify the features of ALCAPA and may be useful for the purposes of surgical intervention. Full article
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Open AccessEditorial
Publisher’s Note: Continued Publication of Cardiogenetics by MDPI
Cardiogenetics 2020, 10(2), 24; https://0-doi-org.brum.beds.ac.uk/10.3390/cardiogenetics10020005 - 16 Oct 2020
Cited by 1 | Viewed by 464
Abstract
Cardiogenetics was launched in 2011 and it has been published over the past nine years by PAGEPress Publications [...] Full article
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