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Article

Prediction of Esophageal Varices Based on Serum-Ascites Albumin Gradient in Cirrhotic Patients

by 1,2,* and 1
1
Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 72714, Vietnam
2
Department of Gastroenterology, Cho Ray Hospital, Ho Chi Minh City 72713, Vietnam
*
Author to whom correspondence should be addressed.
Academic Editor: David A. Gerber
Gastroenterol. Insights 2021, 12(2), 270-277; https://0-doi-org.brum.beds.ac.uk/10.3390/gastroent12020023
Received: 28 May 2021 / Accepted: 1 June 2021 / Published: 2 June 2021
(This article belongs to the Section Liver)
Background: Ascites and esophageal varices (EV) are the most common complications of portal hypertension, with an incidence of approximately 50%. Since effective preventive modalities have been established for variceal hemorrhage, early detection of EV is critical for primary prevention of bleeding. Serum-ascites albumin gradient (SAAG) can be considered an indirect parameter for the detection of EV and is useful in regions where there is a shortage of human and material resources to perform upper gastrointestinal endoscopy (UGE). The aim was to evaluate the role of serum-ascites albumin gradient (SAAG) in the prediction of esophageal varices (EV) in cirrhotic patients with ascites. Methods: All cirrhotic patients with ascites, identified by ultrasonography, who underwent measurement of SAAG, were included in this study. All patients underwent upper gastrointestinal endoscopy (UGE) for assessment of the presence and size of EV. Results: The study included 80 cirrhotic patients with ascites. The main causes of cirrhosis were alcohol intake (37.5%), hepatitis B virus (25.0%), and hepatitis C virus (15.0%). Patients with SAAG values > 1.75 g/dL demonstrated EV with a sensitivity and specificity of 78.4% and 83.3%, respectively. SAAG values > 1.8 g/dL were associated with the risk of large EV with AUC of 0.856, sensitivity of 88.24%, and specificity of 50.79%. The correlation coefficient (r) between SAAG and EV was 0.429, which was statistically significant (p < 0.001). Conclusions: Cirrhotic patients with SAAG values ≥ 1.8 have a higher risk of large EV. In particular, those with values > 1.9 who have higher possibility of bleeding must undergo upper GI endoscopy. View Full-Text
Keywords: SAAG; esophageal varices; cirrhosis SAAG; esophageal varices; cirrhosis
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MDPI and ACS Style

Thong, V.D.; Anh, H.T.V. Prediction of Esophageal Varices Based on Serum-Ascites Albumin Gradient in Cirrhotic Patients. Gastroenterol. Insights 2021, 12, 270-277. https://0-doi-org.brum.beds.ac.uk/10.3390/gastroent12020023

AMA Style

Thong VD, Anh HTV. Prediction of Esophageal Varices Based on Serum-Ascites Albumin Gradient in Cirrhotic Patients. Gastroenterology Insights. 2021; 12(2):270-277. https://0-doi-org.brum.beds.ac.uk/10.3390/gastroent12020023

Chicago/Turabian Style

Thong, Vo D., and Ho T.V. Anh 2021. "Prediction of Esophageal Varices Based on Serum-Ascites Albumin Gradient in Cirrhotic Patients" Gastroenterology Insights 12, no. 2: 270-277. https://0-doi-org.brum.beds.ac.uk/10.3390/gastroent12020023

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