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Case Report

Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers

Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Headley Way, Headington, Oxford OX3 9DU, UK
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Author to whom correspondence should be addressed.
Academic Editor: Maurizio Aricò
Received: 7 March 2021 / Revised: 7 June 2021 / Accepted: 29 June 2021 / Published: 1 July 2021
Infantile hemangiomas are common benign vascular tumors but are rarely found in an intracranial location. Our literature review identified 41 reported cases. There is no general consensus on management of these rare lesions and until recently, treatment was limited to surgery or pharmacological management with steroids or interferon. Although beta-blockers have been widely prescribed in the treatment of cutaneous infantile hemangiomas since 2008, their use in the treatment of intracranial infantile hemangiomas has been minimal. We present a case of infantile hemangioma affecting the right orbit, associated with intracranial extension, causing intermittent right facial nerve palsy. The patient achieved an excellent outcome following combined treatment with oral propranolol and topical timolol maleate 0.5%, with complete regression of the lesion by 4 months. We conclude that beta-blockers are a safe and effective treatment of intracranial infantile hemangiomas and can be employed as first-line management of these lesions. View Full-Text
Keywords: intracranial infantile hemangioma; beta-blockers; propranolol; timolol intracranial infantile hemangioma; beta-blockers; propranolol; timolol
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MDPI and ACS Style

Naughton, A.; Ong, A.Y.; Hildebrand, G.D. Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers. Pediatr. Rep. 2021, 13, 347-356. https://0-doi-org.brum.beds.ac.uk/10.3390/pediatric13030043

AMA Style

Naughton A, Ong AY, Hildebrand GD. Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers. Pediatric Reports. 2021; 13(3):347-356. https://0-doi-org.brum.beds.ac.uk/10.3390/pediatric13030043

Chicago/Turabian Style

Naughton, Aoife, Ariel Y. Ong, and Goran D. Hildebrand 2021. "Safe and Effective Treatment of Intracranial Infantile Hemangiomas with Beta-Blockers" Pediatric Reports 13, no. 3: 347-356. https://0-doi-org.brum.beds.ac.uk/10.3390/pediatric13030043

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