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Article

Momordica charantia Ethanol Extract Attenuates H2O2-Induced Cell Death by Its Antioxidant and Anti-Apoptotic Properties in Human Neuroblastoma SK-N-MC Cells

1
Research Institute, Seoul Medical Center, Seoul 02053, Korea
2
Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Korea
3
Department of Neurosurgery, Seoul Medical Center, Seoul 02053, Korea
*
Author to whom correspondence should be addressed.
Current address: Seoul Medical Center, 156 Shinnea-ro, Seoul 02053, Korea.
Received: 10 September 2018 / Revised: 20 September 2018 / Accepted: 22 September 2018 / Published: 24 September 2018
(This article belongs to the Special Issue Phytochemicals in Health and Disease)
Oxidative stress, which is induced by reactive oxygen species (ROS), causes cellular damage which contributes to the pathogenesis of neurodegenerative diseases. Momordica charantia (MC), a traditional medicinal plant, is known to have a variety of health benefits, such as antidiabetic, anti-inflammatory, and antioxidant effects. However, it is unknown whether MC has protective effects against oxidative stress-induced neuronal cell death. The aim of this study was to investigate the potential action of MC on oxidative stress induced by H2O2. First, we tested whether the pretreatment of Momordica charantia ethanol extract (MCEE) attenuates H2O2-induced cell death in human neuroblastoma SK-N-MC cells. MCEE pretreatment significantly improved cell viability and apoptosis that deteriorated by H2O2. Further, MCEE ameliorated the imbalance between intracellular ROS production and removal through the enhancement of the intracellular antioxidant system. Intriguingly, the inhibition of apoptosis was followed by the blockage of mitochondria-dependent cell death cascades and suppression of the phosphorylation of the mitogen-activated protein kinase signaling (MAPKs) pathway by MCEE. Taken together, MCEE was shown to be effective in protecting against H2O2-induced cell death through its antioxidant and anti-apoptotic properties. View Full-Text
Keywords: Momordica charantia; oxidative stress; reactive oxygen species; neuroprotection; antioxidant; anti-apoptosis; SK-N-MC cells; neurodegenerative disease Momordica charantia; oxidative stress; reactive oxygen species; neuroprotection; antioxidant; anti-apoptosis; SK-N-MC cells; neurodegenerative disease
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MDPI and ACS Style

Kim, K.B.; Lee, S.; Kang, I.; Kim, J.-H. Momordica charantia Ethanol Extract Attenuates H2O2-Induced Cell Death by Its Antioxidant and Anti-Apoptotic Properties in Human Neuroblastoma SK-N-MC Cells. Nutrients 2018, 10, 1368. https://0-doi-org.brum.beds.ac.uk/10.3390/nu10101368

AMA Style

Kim KB, Lee S, Kang I, Kim J-H. Momordica charantia Ethanol Extract Attenuates H2O2-Induced Cell Death by Its Antioxidant and Anti-Apoptotic Properties in Human Neuroblastoma SK-N-MC Cells. Nutrients. 2018; 10(10):1368. https://0-doi-org.brum.beds.ac.uk/10.3390/nu10101368

Chicago/Turabian Style

Kim, Kkot B., SeonAh Lee, Inhae Kang, and Jung-Hee Kim. 2018. "Momordica charantia Ethanol Extract Attenuates H2O2-Induced Cell Death by Its Antioxidant and Anti-Apoptotic Properties in Human Neuroblastoma SK-N-MC Cells" Nutrients 10, no. 10: 1368. https://0-doi-org.brum.beds.ac.uk/10.3390/nu10101368

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