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Review

Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

1
Bureau of Nutritional Sciences, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON K1A 0K9, Canada
2
Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE 68588-6205, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Received: 16 October 2018 / Revised: 6 November 2018 / Accepted: 9 November 2018 / Published: 12 November 2018
(This article belongs to the Special Issue Impact of Bioactive Peptides on Human Health)
Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment. View Full-Text
Keywords: bioactive peptides; enzymatic hydrolysis; fermentation; peptide absorption; oral bioavailability; functional foods bioactive peptides; enzymatic hydrolysis; fermentation; peptide absorption; oral bioavailability; functional foods
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MDPI and ACS Style

Chakrabarti, S.; Guha, S.; Majumder, K. Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients 2018, 10, 1738. https://0-doi-org.brum.beds.ac.uk/10.3390/nu10111738

AMA Style

Chakrabarti S, Guha S, Majumder K. Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients. 2018; 10(11):1738. https://0-doi-org.brum.beds.ac.uk/10.3390/nu10111738

Chicago/Turabian Style

Chakrabarti, Subhadeep, Snigdha Guha, and Kaustav Majumder. 2018. "Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities" Nutrients 10, no. 11: 1738. https://0-doi-org.brum.beds.ac.uk/10.3390/nu10111738

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