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Article

Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1/Substance P Axis

1
Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piauí, Av. São Sebastião, nº 2819, CEP 64202-02, Parnaíba, PI, Brazil
2
Department of Physiology and Pharmacology, Federal University of Ceará, CEP 60430-270, Fortaleza, Ceará, Brazil
3
Postgraduate Program in Morphofunctional Sciences, Department of Morphology, Faculty of Medicine, Federal University Ceará, CEP 60430-170, Fortaleza-CE, Brazil
*
Author to whom correspondence should be addressed.
Received: 3 October 2018 / Revised: 5 November 2018 / Accepted: 20 November 2018 / Published: 21 January 2019
This study aimed to evaluate the effect of Lactobacillus reuteri DSM 17938 (DSM) on ethanol-induced gastric injury, and if its possible mechanism of action is related to inhibiting the transient receptor potential vanilloid type 1 (TRPV1). We evaluated the effect of supplementing 108 CFU•g body wt−1•day−1 of DSM on ethanol-induced gastric injury. DSM significantly reduced the ulcer area (1.940 ± 1.121 mm2) with 3 days of pretreatment. The effects of DSM supplementation were reversed by Resiniferatoxin (RTX), TRPV1 agonist (3 nmol/kg p.o.). Substance P (SP) (1 μmol/L per 20 g) plus 50% ethanol resulted in hemorrhagic lesions, and DSM supplementation did not reverse the lesion area induced by administering SP. TRPV1 staining intensity was lower, SP, malondialdehyde (MDA) and nitrite levels were reduced, and restored normal levels of antioxidant parameters (glutathione and superoxide dismutase) in the gastric mucosa in mice treated with DSM. In conclusion, DSM exhibited gastroprotective activity through decreased expression of TRPV1 receptor and decreasing SP levels, with a consequent reduction of oxidative stress. View Full-Text
Keywords: gastritis; alcohol; probiotic; TRPV; neurokinin gastritis; alcohol; probiotic; TRPV; neurokinin
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MDPI and ACS Style

Oliveira, A.P.; Souza, L.K.M.; Araújo, T.S.L.; Araújo, S.d.; Nogueira, K.M.; Sousa, F.B.M.; Silva, R.O.; Pacífico, D.M.; Martins, C.S.; Brito, G.A.d.C.; Souza, M.H.L.P.; Medeiros, J.V.R. Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1/Substance P Axis. Nutrients 2019, 11, 208. https://0-doi-org.brum.beds.ac.uk/10.3390/nu11010208

AMA Style

Oliveira AP, Souza LKM, Araújo TSL, Araújo Sd, Nogueira KM, Sousa FBM, Silva RO, Pacífico DM, Martins CS, Brito GAdC, Souza MHLP, Medeiros JVR. Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1/Substance P Axis. Nutrients. 2019; 11(1):208. https://0-doi-org.brum.beds.ac.uk/10.3390/nu11010208

Chicago/Turabian Style

Oliveira, Ana P., Luan K.M. Souza, Thiago S.L. Araújo, Simone d. Araújo, Kerolayne M. Nogueira, Francisca B.M. Sousa, Renan O. Silva, Dvison M. Pacífico, Conceição S. Martins, Gerly A.d.C. Brito, Marcellus H.L.P. Souza, and Jand V.R. Medeiros 2019. "Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1/Substance P Axis" Nutrients 11, no. 1: 208. https://0-doi-org.brum.beds.ac.uk/10.3390/nu11010208

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