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Article

Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation

1
Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, Department of Orthopedics, Tri-Service General Hospital, Taipei 114, Taiwan
2
Department of Orthopedics, Tri-Service General Hospital, Taipei, Department of Orthopedics, Tri-Service General Hospital, Taipei 114, Taiwan
3
Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore
4
Department of Orthopedics, College of Medicine, School of Medicine, Taipei Medical University, Taipei Medical University Hospital, Taipei 114, Taiwan
5
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
6
School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan
*
Author to whom correspondence should be addressed.
Received: 29 April 2019 / Revised: 21 May 2019 / Accepted: 24 May 2019 / Published: 27 May 2019
(This article belongs to the Special Issue Arthritis and Nutrition: Can Food Be Medicine?)
Genistein is an isoflavone extracted from soybean (Glycine max). This compound has anti-inflammatory, anti-oxidative, and anti-cancer effects; however, the mechanism underlying the effects of genistein on IL-1β-stimulated human osteoarthritis (OA) chondrocytes remains unknown. Our objectives in this study were to explore the anti-inflammatory effects of genistein on IL-1β-stimulated human OA chondrocytes and to investigate the potential mechanisms which underlie them. Our results from an in-vitro model of osteoarthritis indicate that genistein inhibits the IL-1β-induced expression of the catabolic factors nitric oxide synthase 2 (NOS2), cyclooxygenase 2 (COX-2), and matrix metalloproteinases (MMPs). Genistein was shown to stimulate Ho-1 expression, which has been associated with Nrf-2 pathway activation in human chondrocytes. In a rat model, genistein was also shown to attenuate the progression of traumatic osteoarthritis. Taken together, these results demonstrate the effectiveness of genistein in mediating the inflammation associated with joint disorders. Our results also indicate that genistein could potentially serve as an alternative therapeutic treatment for OA. View Full-Text
Keywords: osteoarthritis; genistein; IL-1β; inflammation osteoarthritis; genistein; IL-1β; inflammation
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MDPI and ACS Style

Liu, F.-C.; Wang, C.-C.; Lu, J.-W.; Lee, C.-H.; Chen, S.-C.; Ho, Y.-J.; Peng, Y.-J. Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation. Nutrients 2019, 11, 1180. https://0-doi-org.brum.beds.ac.uk/10.3390/nu11051180

AMA Style

Liu F-C, Wang C-C, Lu J-W, Lee C-H, Chen S-C, Ho Y-J, Peng Y-J. Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation. Nutrients. 2019; 11(5):1180. https://0-doi-org.brum.beds.ac.uk/10.3390/nu11051180

Chicago/Turabian Style

Liu, Feng-Cheng, Chih-Chien Wang, Jeng-Wei Lu, Chian-Her Lee, Shao-Chi Chen, Yi-Jung Ho, and Yi-Jen Peng. 2019. "Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation" Nutrients 11, no. 5: 1180. https://0-doi-org.brum.beds.ac.uk/10.3390/nu11051180

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