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Article

Intermittent Fasting and High-Intensity Exercise Elicit Sexual-Dimorphic and Tissue-Specific Adaptations in Diet-Induced Obese Mice

1
Institute for Health and Sport, Victoria University, Footscray, VIC 3011, Australia
2
Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, St Albans, VIC 3021, Australia
3
Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St Albans, VIC 3021, Australia
4
Department of Health and Medical Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
*
Author to whom correspondence should be addressed.
Received: 22 May 2020 / Revised: 7 June 2020 / Accepted: 10 June 2020 / Published: 12 June 2020
(This article belongs to the Special Issue Nutrients, Metabolism and Obesity Prevention)
The molecular adaptations that underpin body composition changes and health benefits of intermittent fasting (IF) and high-intensity interval training (HIIT) are unclear. The present study investigated these adaptations within the hypothalamus, white adipose and skeletal muscle tissue following 12 weeks of IF and/or HIIT in diet-induced obese mice. Mice (C57BL/6, 8-week-old, males/females) were fed high-fat (59%) and sugar (30%) water (HF/S) for 12 weeks followed by an additional 12 weeks of HF/S plus either IF, HIIT, combination (IF+HIIT) or HF/S only control (CON). Tissues were harvested at 12 and 24 weeks and analysed for various molecular markers. Hypothalamic NPY expression was significantly lower following IF+HIIT compared to CON in females. In adipose tissue, leptin expression was significantly lower following IF and IF+HIIT compared to CON in males and females. Males demonstrated increased markers of fat oxidation (HADH, FABP4) following IF+HIIT, whereas females demonstrated reduced markers of adipocyte differentiation/storage (CIDEC and FOXO1) following IF and/or IF+HIIT. In muscle, SIRT1, UCP3, PGC1α, and AS160 expression was significantly lower following IF compared to CON in males and/or females. This investigation suggests that males and females undertaking IF and HIIT may prevent weight gain via different mechanisms within the same tissue. View Full-Text
Keywords: microRNA; genes; adipose; hypothalamus; muscle microRNA; genes; adipose; hypothalamus; muscle
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MDPI and ACS Style

Wilson, R.A.; Stathis, C.G.; Hayes, A.; Cooke, M.B. Intermittent Fasting and High-Intensity Exercise Elicit Sexual-Dimorphic and Tissue-Specific Adaptations in Diet-Induced Obese Mice. Nutrients 2020, 12, 1764. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12061764

AMA Style

Wilson RA, Stathis CG, Hayes A, Cooke MB. Intermittent Fasting and High-Intensity Exercise Elicit Sexual-Dimorphic and Tissue-Specific Adaptations in Diet-Induced Obese Mice. Nutrients. 2020; 12(6):1764. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12061764

Chicago/Turabian Style

Wilson, Robin A., Christos G. Stathis, Alan Hayes, and Matthew B. Cooke 2020. "Intermittent Fasting and High-Intensity Exercise Elicit Sexual-Dimorphic and Tissue-Specific Adaptations in Diet-Induced Obese Mice" Nutrients 12, no. 6: 1764. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12061764

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