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The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial

1
Department of Physiology, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Knoxville, TN 37934, USA
2
Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA
3
Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Giovanna Trinchese and Maria Pina Mollica
Received: 2 September 2021 / Revised: 11 October 2021 / Accepted: 13 October 2021 / Published: 15 October 2021
Interventions to decrease inflammation and improve metabolic function hold promise for the prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and diabetes following MSM treatment. However, the effects of MSM on obesity-related diseases in humans have not been investigated. Therefore, the purpose of this investigation was to determine whether MSM supplementation improves cardiometabolic health, and markers of inflammation and oxidative status. A randomized, double-blind, placebo-controlled design was utilized with a total of 22 overweight or obese adults completing the study. Participants received either a placebo (white rice flour) or 3 g MSM daily for 16 weeks. Measurements occurred at baseline and after 4, 8, and 16 weeks. Outcome measures included fasting glucose, insulin, blood lipids, blood pressure, body composition, metabolic rate, and markers of inflammation and oxidative status. The primary finding of this work shows that high-density lipoprotein cholesterol was elevated at 8 and 16 weeks of daily MSM consumption compared to baseline, (p = 0.008, p = 0.013). Our findings indicate that MSM supplementation may improve the cholesterol profile by resulting in higher levels of high-density lipoprotein cholesterol. View Full-Text
Keywords: methylsulfonylmethane; cardiometabolic; inflammation; overweight; obesity methylsulfonylmethane; cardiometabolic; inflammation; overweight; obesity
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MDPI and ACS Style

Miller, L.; Thompson, K.; Pavlenco, C.; Mettu, V.S.; Haverkamp, H.; Skaufel, S.; Basit, A.; Prasad, B.; Larsen, J. The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. Nutrients 2021, 13, 3620. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13103620

AMA Style

Miller L, Thompson K, Pavlenco C, Mettu VS, Haverkamp H, Skaufel S, Basit A, Prasad B, Larsen J. The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. Nutrients. 2021; 13(10):3620. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13103620

Chicago/Turabian Style

Miller, Lindsey, Kari Thompson, Carolina Pavlenco, Vijaya S. Mettu, Hans Haverkamp, Samantha Skaufel, Abdul Basit, Bhagwat Prasad, and Julie Larsen. 2021. "The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial" Nutrients 13, no. 10: 3620. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13103620

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