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An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health
Article

Increased Omega-3 Fatty Acid Intake Is Inversely Associated with Subclinical Inflammation in Healthy Elderly Men, Based on the 2015–2018 Korean National Health and Nutrition Examination Survey

1
Department of Family Medicine, Chungbuk National University Hospital, Cheongju 28644, Korea
2
Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Korea
3
Department of Family Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Korea
*
Author to whom correspondence should be addressed.
Received: 2 December 2020 / Revised: 20 January 2021 / Accepted: 22 January 2021 / Published: 24 January 2021
(This article belongs to the Special Issue Marine Omega-3s and Human Health)
(1) Background: Subclinical inflammation as a risk factor of cardiovascular diseases was clinically measured using C-reactive protein (CRP) level. (2) Methods: This study was cross-sectionally designed based the 2015–2018 Korean National Health and Nutrition Examination Survey (KNHANES). The ratio of daily omega-3 fatty acids to energy intake (ω3FA ratio) was classified into four quartile groups (Q1, <0.3%; Q2, 0.3%–<0.6%; Q3, 0.6%–<1.0%; and Q4, ≥1.0% in both sexes). Logistic regression analysis was conducted to investigate the association between the ω3FA ratio and subclinical inflammation defined as CRP levels ≥3 mg/dL. (3) Results: The ω3FA ratio in subjects without and with subclinical inflammation was 0.8% and 0.7% in men (p-value = 0.001), and 0.8% and 0.8% in women (p-value = 0.491), respectively. The prevalence of subclinical inflammation in males decreased with increasing quartile of ω3FA ratio (12.9%, 9.6%, 7.4%, and 7.7%, p-value = 0.033), while female prevalence was not significant among quartile groups. Compared to Q1, odds ratios (95% confidence intervals) for subclinical inflammation of Q2, Q3, and Q4 were 0.740 (0.465–1.177), 0.564 (0.341–0.930), and 0.549 (0.317–0.953) in males, and 1.066 (0.653–1.741), 1.105 (0.600–1.718), and 0.934 (0.556–1.571) in females after full adjustment. (4) Conclusion: The ω3FA ratio is associated with subclinical inflammation in men. View Full-Text
Keywords: omega-3 fatty acids; C-reactive protein; subclinical inflammation; cardiovascular disease; omega-3 fatty acid ratio omega-3 fatty acids; C-reactive protein; subclinical inflammation; cardiovascular disease; omega-3 fatty acid ratio
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MDPI and ACS Style

Yang, W.; Lee, J.H.; Lee, J.-w.; Kim, Y.; Kim, Y.-S.; You, H.-S.; Kang, H.-T. Increased Omega-3 Fatty Acid Intake Is Inversely Associated with Subclinical Inflammation in Healthy Elderly Men, Based on the 2015–2018 Korean National Health and Nutrition Examination Survey. Nutrients 2021, 13, 338. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020338

AMA Style

Yang W, Lee JH, Lee J-w, Kim Y, Kim Y-S, You H-S, Kang H-T. Increased Omega-3 Fatty Acid Intake Is Inversely Associated with Subclinical Inflammation in Healthy Elderly Men, Based on the 2015–2018 Korean National Health and Nutrition Examination Survey. Nutrients. 2021; 13(2):338. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020338

Chicago/Turabian Style

Yang, Woojung, Jong H. Lee, Jae-woo Lee, Yonghwan Kim, Ye-Seul Kim, Hyo-Sun You, and Hee-Taik Kang. 2021. "Increased Omega-3 Fatty Acid Intake Is Inversely Associated with Subclinical Inflammation in Healthy Elderly Men, Based on the 2015–2018 Korean National Health and Nutrition Examination Survey" Nutrients 13, no. 2: 338. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020338

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