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Cow’s Milk Protein Allergy as a Model of Food Allergies
Article

The Use of an Amino Acid Formula Containing Synbiotics in Infants with Cow’s Milk Protein Allergy—Effect on Clinical Outcomes

1
Medical Affairs, Nutricia Ltd., White Horse Business Park, Trowbridge BA14 0XQ, UK
2
Institute of Human Nutrition, Faculty of Medicine, Mailpoint 113, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
3
Department of Nutrition and Dietetics, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol BS2 8BJ, UK
4
Cegedim Health Data, Cegedim Rx, London SW8 3QJ, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Diego Peroni, Gian Vincenzo Zuccotti, Elvira Verduci and Francisco J. Pérez-Cano
Received: 22 April 2021 / Revised: 11 June 2021 / Accepted: 25 June 2021 / Published: 27 June 2021
(This article belongs to the Special Issue New Insights into Cow's Milk and Allergy)
Cow’s milk protein allergy (CMPA) is common and costly. Clinical trials of infants with CMPA have shown that the use of an amino acid formula containing pre- and probiotics (synbiotics) (AAF-Syn) may lead to significant reductions in infections, medication prescriptions and hospital admissions, compared to AAF without synbiotics. These effects have not yet been confirmed in real-world practice. This retrospective matched cohort study examined clinical and healthcare data from The Health Improvement Network database, from 148 infants with CMPA (54% male, mean age at diagnosis 4.69 months), prescribed either AAF-Syn (probiotic Bifidobacterium breve M16-V and prebiotics, including chicory-derived oligo-fructose and long-chain inulin) or AAF. AAF-Syn was associated with fewer symptoms (−37%, p < 0.001), infections (−35%, p < 0.001), medication prescriptions (−19%, p < 0.001) and healthcare contacts (−18%, p = 0.15) vs. AAF. Infants prescribed AAF-Syn had a significantly higher probability of achieving asymptomatic management without hypoallergenic formula (HAF) (adjusted HR 3.70, 95% CI 1.97–6.95, p < 0.001), with a shorter clinical course of symptoms (median time to asymptomatic management without HAF 1.35 years vs. 1.95 years). AAF-Syn was associated with potential cost-savings of £452.18 per infant over the clinical course of symptoms. These findings may be attributable to the effect of the specific synbiotic on the gut microbiome. Further research is warranted to explore this. This real-world study provides evidence consistent with clinical trials that AAF-Syn may produce clinical and healthcare benefits with potential economic impact. View Full-Text
Keywords: paediatrics; dietetics; cow’s milk protein allergy; synbiotics; amino acid formula; infections paediatrics; dietetics; cow’s milk protein allergy; synbiotics; amino acid formula; infections
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MDPI and ACS Style

Sorensen, K.; Cawood, A.L.; Cooke, L.H.; Acosta-Mena, D.; Stratton, R.J. The Use of an Amino Acid Formula Containing Synbiotics in Infants with Cow’s Milk Protein Allergy—Effect on Clinical Outcomes. Nutrients 2021, 13, 2205. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13072205

AMA Style

Sorensen K, Cawood AL, Cooke LH, Acosta-Mena D, Stratton RJ. The Use of an Amino Acid Formula Containing Synbiotics in Infants with Cow’s Milk Protein Allergy—Effect on Clinical Outcomes. Nutrients. 2021; 13(7):2205. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13072205

Chicago/Turabian Style

Sorensen, Katy, Abbie L. Cawood, Lisa H. Cooke, Dionisio Acosta-Mena, and Rebecca J. Stratton 2021. "The Use of an Amino Acid Formula Containing Synbiotics in Infants with Cow’s Milk Protein Allergy—Effect on Clinical Outcomes" Nutrients 13, no. 7: 2205. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13072205

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