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Article

Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children’s Study

1
Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan
2
Medical Support Center for the Japan Environment and Children’s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan
*
Author to whom correspondence should be addressed.
Membership of the JECS Group is Provided in the Acknowledgments.
Academic Editor: Andrea Fabbri
Received: 4 July 2021 / Revised: 10 August 2021 / Accepted: 10 August 2021 / Published: 12 August 2021
(This article belongs to the Section Micronutrients and Human Health)
Vitamin D (VitD) may affect immune system modulation and result in the development of atopic dermatitis (AD). However, published findings have remained controversial. We investigated the association between early-life 25-hydroxyvitamin D (25(OH)D) levels and AD risk at childhood with a birth cohort. The data were obtained from “the Japan Environment and Children’s Study (JECS)” and “the Sub-Cohort study of JECS” performed with children aged 2 years. “Liquid chromatography-tandem mass spectrometry” was used to measure VitD. The information on AD was obtained from parents’ answers to a questionnaire when their children were aged 3 years. In order to explain the seasonal effects on VitD levels, a deseasonalized continuous variable was further calculated. The logistic regression models were fitted to evaluate the effect of VitD on childhood AD. The study included 4378 children with complete data on VitD and AD. The results from models indicated that low VitD at 2 years was not a risk factor for the development of AD at 3 years, after adjusting for potential confounders. Moreover, there was no U-shape relationship between deseasonalized VitD and childhood AD. Overall, early-life 25(OH)D levels were not link to the increased risk of developing childhood AD. View Full-Text
Keywords: 25-hydroxyvitamin D; vitamin D; deficiency; insufficiency; children; atopic dermatitis 25-hydroxyvitamin D; vitamin D; deficiency; insufficiency; children; atopic dermatitis
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MDPI and ACS Style

Yang, L.; Sato, M.; Saito-Abe, M.; Nishizato, M.; Mezawa, H.; Yamamoto-Hanada, K.; Ohya, Y.; The Japan Environment and Children’s Study Group. Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children’s Study. Nutrients 2021, 13, 2761. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082761

AMA Style

Yang L, Sato M, Saito-Abe M, Nishizato M, Mezawa H, Yamamoto-Hanada K, Ohya Y, The Japan Environment and Children’s Study Group. Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children’s Study. Nutrients. 2021; 13(8):2761. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082761

Chicago/Turabian Style

Yang, Limin, Miori Sato, Mayako Saito-Abe, Minaho Nishizato, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Yukihiro Ohya, and The Japan Environment and Children’s Study Group. 2021. "Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children’s Study" Nutrients 13, no. 8: 2761. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082761

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