Next Article in Journal
A Review of the Properties of Anthocyanins and Their Influence on Factors Affecting Cardiometabolic and Cognitive Health
Next Article in Special Issue
Maternal High-Fat Diet Modulates Cnr1 Gene Expression in Male Rat Offspring
Previous Article in Journal
Increasing Fruit and Vegetable Variety over Time Is Associated with Lower 15-Year Healthcare Costs: Results from the Australian Longitudinal Study on Women’s Health
Previous Article in Special Issue
Effect of Dietary Fatty Acids on MicroRNA Expression Related to Metabolic Disorders and Inflammation in Human and Animal Trials
Review

Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases

1
Brazilian Center for Research in Energy and Materials (CNPEM), Brazilian Biosciences National Laboratory (LNBio), Polo II de Alta Tecnologia—R. Giuseppe Máximo Scolfaro, Campinas 13083-100, Brazil
2
Graduate Program in Pharmaceutical Sciences, Faculty Pharmaceutical Sciences, University of Campinas, Campinas 13083-970, Brazil
3
Graduate Program in Functional and Molecular Biology, Institute of Biology, State University of Campinas (Unicamp), Campinas 13083-970, Brazil
4
Brazilian Center for Research in Energy and Materials (CNPEM), Brazilian Biorenewables National Laboratory (LNBR), Polo II de Alta Tecnologia—R. Giuseppe Máximo Scolfaro, Campinas 13083-100, Brazil
*
Authors to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editor: Sebastiano Banni
Received: 28 June 2021 / Revised: 9 August 2021 / Accepted: 11 August 2021 / Published: 18 August 2021
(This article belongs to the Special Issue Fat Diets and Metabolic Diseases)
Throughout the 20th and 21st centuries, the incidence of non-communicable diseases (NCDs), also known as chronic diseases, has been increasing worldwide. Changes in dietary and physical activity patterns, along with genetic conditions, are the main factors that modulate the metabolism of individuals, leading to the development of NCDs. Obesity, diabetes, metabolic associated fatty liver disease (MAFLD), and cardiovascular diseases (CVDs) are classified in this group of chronic diseases. Therefore, understanding the underlying molecular mechanisms of these diseases leads us to develop more accurate and effective treatments to reduce or mitigate their prevalence in the population. Given the global relevance of NCDs and ongoing research progress, this article reviews the current understanding about NCDs and their related risk factors, with a focus on obesity, diabetes, MAFLD, and CVDs, summarizing the knowledge about their pathophysiology and highlighting the currently available and emerging therapeutic strategies, especially pharmacological interventions. All of these diseases play an important role in the contamination by the SARS-CoV-2 virus, as well as in the progression and severity of the symptoms of the coronavirus disease 2019 (COVID-19). Therefore, we briefly explore the relationship between NCDs and COVID-19. View Full-Text
Keywords: NCDs; obesity; diabetes; MAFLD; cardiovascular diseases; metabolism NCDs; obesity; diabetes; MAFLD; cardiovascular diseases; metabolism
Show Figures

Graphical abstract

MDPI and ACS Style

Guerra, J.V.S.; Dias, M.M.G.; Brilhante, A.J.V.C.; Terra, M.F.; García-Arévalo, M.; Figueira, A.C.M. Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases. Nutrients 2021, 13, 2830. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082830

AMA Style

Guerra JVS, Dias MMG, Brilhante AJVC, Terra MF, García-Arévalo M, Figueira ACM. Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases. Nutrients. 2021; 13(8):2830. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082830

Chicago/Turabian Style

Guerra, João V.S., Marieli M.G. Dias, Anna J.V.C. Brilhante, Maiara F. Terra, Marta García-Arévalo, and Ana C.M. Figueira. 2021. "Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases" Nutrients 13, no. 8: 2830. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082830

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop