Next Article in Journal
Human Breast Milk Composition and Function in Human Health: From Nutritional Components to Microbiome and MicroRNAs
Next Article in Special Issue
The Effects of a Ketogenic Diet on Patients with Dihydrolipoamide Dehydrogenase Deficiency
Previous Article in Journal
The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study
Previous Article in Special Issue
Slow but Steady—The Responsiveness of Sympathoadrenal System to a Hypoglycemic Challenge in Ketogenic Diet-Fed Rats
Article

Dietary-Induced Ketogenesis: Adults Are Not Children

1
Pediatric Neurology Institute, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel HaShomer, Ramat Gan 52621, Israel
2
Institute of Oncology, Sheba Medical Center, Tel HaShomer, Ramat Gan 52621, Israel
3
Sackler School of Medicine, Tel Aviv University, Tel-Aviv 6997801, Israel
4
Department of Radiation Oncology, Sheba Medical Center, Tel HaShomer, Ramat Gan 52621, Israel
5
Department of Radiation Oncology, Duke University, Durham, NC 27710, USA
6
Metabolic Diseases Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel HaShomer, Ramat Gan 52621, Israel
7
Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jane Shearer, Marina Mourtzakis and Matthias Klein
Received: 11 August 2021 / Revised: 28 August 2021 / Accepted: 30 August 2021 / Published: 2 September 2021
(This article belongs to the Special Issue Ketogenic Diet and Metabolism)
There is increasing interest in the use of a ketogenic diet for various adult disorders; however, the ability of adults to generate ketones is unknown. Our goal was to challenge the hypothesis that there would be no difference between adults and children regarding their ability to enter ketosis. Methods: Two populations were studied, both treated with identical very low-carbohydrate high-fat diets: a retrospective series of children with epilepsy or/and metabolic disorders (2009–2016) and a prospective clinical trial of adults with glioblastoma. Dietary intake was assessed based upon written food diaries and 24-h dietary recall. Ketogenic ratio was calculated according to [grams of fat consumed]/[grams of carbohydrate and protein consumed]. Ketone levels (β-hydroxybutyrate) were measured in blood and/or urine. Results: A total of 168 encounters amongst 28 individuals were analyzed. Amongst both children and adults, ketone levels correlated with nutritional ketogenic ratio; however, the absolute ketone levels in adults were approximately one quarter of those seen in children. This difference was highly significant in a multivariate linear regression model, p < 0.0001. Conclusions: For diets with comparable ketogenic ratios, adults have lower blood ketone levels than children; consequently, high levels of nutritional ketosis are unobtainable in adults. View Full-Text
Keywords: ketogenic diet; ketogenesis; glioblastoma; epilepsy; age-related differences ketogenic diet; ketogenesis; glioblastoma; epilepsy; age-related differences
Show Figures

Figure 1

MDPI and ACS Style

Porper, K.; Zach, L.; Shpatz, Y.; Ben-Zeev, B.; Tzadok, M.; Jan, E.; Talianski, A.; Champ, C.E.; Symon, Z.; Anikster, Y.; Lawrence, Y.R. Dietary-Induced Ketogenesis: Adults Are Not Children. Nutrients 2021, 13, 3093. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093093

AMA Style

Porper K, Zach L, Shpatz Y, Ben-Zeev B, Tzadok M, Jan E, Talianski A, Champ CE, Symon Z, Anikster Y, Lawrence YR. Dietary-Induced Ketogenesis: Adults Are Not Children. Nutrients. 2021; 13(9):3093. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093093

Chicago/Turabian Style

Porper, Keren, Leor Zach, Yael Shpatz, Bruria Ben-Zeev, Michal Tzadok, Elisheva Jan, Alisa Talianski, Colin E. Champ, Zvi Symon, Yair Anikster, and Yaacov R. Lawrence. 2021. "Dietary-Induced Ketogenesis: Adults Are Not Children" Nutrients 13, no. 9: 3093. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093093

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop