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Article

Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans

1
Department of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
2
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea
3
Department of Family Medicine, Yongin Severance Hospital, Yongin 16995, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: John Mamo, Ryu Takechi and Virginie Lam
Received: 30 June 2021 / Revised: 12 September 2021 / Accepted: 14 September 2021 / Published: 16 September 2021
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
The atherogenic index of plasma (AIP), composed of triglycerides and high-density lipoprotein cholesterol, is a novel critical marker for assessing the risk of atherogenicity and cardiometabolic health. We aimed to prospectively study the association between AIP and incident ischemic heart disease (IHD) risk in a large cohort of non-diabetic Korean adults. Data were assessed from 17,944 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. The participants were divided into four groups according to AIP quartiles, calculated as log (triglyceride/high-density lipoprotein cholesterol). We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional-hazard regression models over a 50-month period that followed the baseline survey. During the follow-up period, 332 participants (1.9%) developed IHD. HRs of IHD for AIP quartiles 2–4 were 1.58 (95% CI, 1.03–2.43), 1.82 (95% CI, 1.20–2.78), and 2.11 (95% CI, 1.37–3.24) after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, fasting plasma glucose, high-sensitivity C-reactive protein level, and hypertension medication. Higher AIP levels may precede and predict the development of IHD in non-diabetic Korean adults. View Full-Text
Keywords: atherogenic index of plasma; triglycerides; cardiometabolic risk; cohort study; ischemic heart disease atherogenic index of plasma; triglycerides; cardiometabolic risk; cohort study; ischemic heart disease
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MDPI and ACS Style

Kim, J.J.; Yoon, J.; Lee, Y.-J.; Park, B.; Jung, D.-H. Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans. Nutrients 2021, 13, 3231. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093231

AMA Style

Kim JJ, Yoon J, Lee Y-J, Park B, Jung D-H. Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans. Nutrients. 2021; 13(9):3231. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093231

Chicago/Turabian Style

Kim, Julie J., Jihyun Yoon, Yong-Jae Lee, Byoungjin Park, and Dong-Hyuk Jung. 2021. "Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans" Nutrients 13, no. 9: 3231. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093231

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