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Article

Association of Nutrition in Early Childhood with Body Composition and Leptin in Later Childhood and Early Adulthood

1
Centre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol BS8 1NU, UK
2
NPTC Nutrition—SBU Nutrition, Avenue Nestle 55, 1800 Vevey, Switzerland
3
Nestlé Institute of Health Sciences, 1000 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editors: Valerie Verhasselt and Lieke van den Elsen
Received: 6 July 2021 / Revised: 14 September 2021 / Accepted: 15 September 2021 / Published: 18 September 2021
(This article belongs to the Special Issue Early-Life Nutrition and Metabolic Disorders in Later Life)
Objectives: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), this study aimed to replicate the finding of the Etude Longitudinale Alimentation Nutrition Croissance des Enfants (ELANCE) that low fat intake in early childhood was associated with increased adiposity in adulthood. Methods: Diet was assessed at 8 and 18 months using 3-day food records. Body composition variables were measured at 9 and 17 years, and serum leptin at 9 years. Associations were modelled using adjusted linear regression. Results: In replication analyses, in contrast to ELANCE, there was a positive association between fat intake (% energy) at 18 months and fat mass (FM) at 9 years (B coefficient 0.10 (95% CI 0.03, 0.20) kg, p = 0.005). There was no association with serum leptin. In extended analyses fat intake at 18 months was positively associated with FM in boys (0.2 (0.00, 0.30), p = 0.008) at 9 years but not in girls. Fat intake was positively associated with serum leptin concentration in boys (0.2 (0.1, 0.4) ng/mL, p = 0.011) but not in girls. Conclusions: Our results did not corroborate the findings from the ELANCE study. A high fat diet in early life may have implications for later childhood and adolescent obesity. View Full-Text
Keywords: ALSPAC; energy; dietary fat; body composition; obesity; leptin ALSPAC; energy; dietary fat; body composition; obesity; leptin
MDPI and ACS Style

Jones, L.R.; Emmett, P.M.; Hays, N.P.; Shahkhalili, Y.; Taylor, C.M. Association of Nutrition in Early Childhood with Body Composition and Leptin in Later Childhood and Early Adulthood. Nutrients 2021, 13, 3264. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093264

AMA Style

Jones LR, Emmett PM, Hays NP, Shahkhalili Y, Taylor CM. Association of Nutrition in Early Childhood with Body Composition and Leptin in Later Childhood and Early Adulthood. Nutrients. 2021; 13(9):3264. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093264

Chicago/Turabian Style

Jones, Louise R., Pauline M. Emmett, Nicholas P. Hays, Yassaman Shahkhalili, and Caroline M. Taylor. 2021. "Association of Nutrition in Early Childhood with Body Composition and Leptin in Later Childhood and Early Adulthood" Nutrients 13, no. 9: 3264. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093264

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