Next Article in Journal
Perennial Ryegrass Alkaloids Increase Respiration Rate and Decrease Plasma Prolactin in Merino Sheep under Both Thermoneutral and Mild Heat Conditions
Previous Article in Journal
Impact of Naturally Contaminated Substrates on Alphitobius diaperinus and Hermetia illucens: Uptake and Excretion of Mycotoxins
Previous Article in Special Issue
From Discovery of Snake Venom Disintegrins to A Safer Therapeutic Antithrombotic Agent
Article

Suppressive Effects of Bee Venom-Derived Phospholipase A2 on Mechanical Allodynia in a Rat Model of Neuropathic Pain

1
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea
2
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
*
Authors to whom correspondence should be addressed.
Received: 10 June 2019 / Revised: 14 August 2019 / Accepted: 15 August 2019 / Published: 19 August 2019
(This article belongs to the Special Issue From Toxins to Drugs)
Bee venom (BV) has a long history of being used in traditional Korean medicine to relieve pain. Here, we investigated the effect of BV-derived phospholipase A2 (bvPLA2), a major component of BV, on peripheral nerve injury-induced neuropathic pain in rats. Spinal nerve ligation (SNL) was performed in Sprague Dawley rats to induce neuropathic pain, and paw withdrawal thresholds were measured using von Frey test. Mechanical allodynia, the representative symptom of neuropathic pain, was manifested following SNL and persisted for several weeks. The repetitive bvPLA2 treatment (0.2 mg/kg/day, i.p.) for two days significantly relieved the SNL-induced mechanical allodynia. The antiallodynic effect of bvPLA2 was blocked by spinal pretreatment with α1-adrenergic antagonist prazosin (30 μg, i.t.) but not with α2-adrenergic antagonist idazoxan (50 μg, i.t.). Also, the spinal application of α1-adrenergic agonist phenylephrine (50 μg, i.t.) reduced mechanical allodynia. These results indicate that bvPLA2 could relieve nerve injury-induced neuropathic mechanical allodynia through the activation of spinal α1-adrenergic receptors. View Full-Text
Keywords: phospholipase A2; bee venom; peripheral nerve injury; neuropathic pain; mechanical allodynia; spinal cord; adrenergic receptor phospholipase A2; bee venom; peripheral nerve injury; neuropathic pain; mechanical allodynia; spinal cord; adrenergic receptor
Show Figures

Figure 1

MDPI and ACS Style

Woo, S.; Chung, G.; Bae, H.; Kim, S.K. Suppressive Effects of Bee Venom-Derived Phospholipase A2 on Mechanical Allodynia in a Rat Model of Neuropathic Pain. Toxins 2019, 11, 477. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins11080477

AMA Style

Woo S, Chung G, Bae H, Kim SK. Suppressive Effects of Bee Venom-Derived Phospholipase A2 on Mechanical Allodynia in a Rat Model of Neuropathic Pain. Toxins. 2019; 11(8):477. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins11080477

Chicago/Turabian Style

Woo, Seunghui, Geehoon Chung, Hyunsu Bae, and Sun K. Kim 2019. "Suppressive Effects of Bee Venom-Derived Phospholipase A2 on Mechanical Allodynia in a Rat Model of Neuropathic Pain" Toxins 11, no. 8: 477. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins11080477

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop