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Inhibition of Pore-Forming Proteins

Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
Author to whom correspondence should be addressed.
Received: 28 June 2019 / Revised: 27 August 2019 / Accepted: 10 September 2019 / Published: 19 September 2019
(This article belongs to the Special Issue Pore-Forming Toxins (PFTs): Never Out of Fashion)
Perforation of cellular membranes by pore-forming proteins can affect cell physiology, tissue integrity, or immune response. Since many pore-forming proteins are toxins or highly potent virulence factors, they represent an attractive target for the development of molecules that neutralize their actions with high efficacy. There has been an assortment of inhibitors developed to specifically obstruct the activity of pore-forming proteins, in addition to vaccination and antibiotics that serve as a plausible treatment for the majority of diseases caused by bacterial infections. Here we review a wide range of potential inhibitors that can specifically and effectively block the activity of pore-forming proteins, from small molecules to more specific macromolecular systems, such as synthetic nanoparticles, antibodies, antibody mimetics, polyvalent inhibitors, and dominant negative mutants. We discuss their mechanism of inhibition, as well as advantages and disadvantages. View Full-Text
Keywords: pore-forming proteins; pore-forming toxins; anthrax toxin; lipid membranes; pore formation; inhibitor pore-forming proteins; pore-forming toxins; anthrax toxin; lipid membranes; pore formation; inhibitor
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MDPI and ACS Style

Omersa, N.; Podobnik, M.; Anderluh, G. Inhibition of Pore-Forming Proteins. Toxins 2019, 11, 545.

AMA Style

Omersa N, Podobnik M, Anderluh G. Inhibition of Pore-Forming Proteins. Toxins. 2019; 11(9):545.

Chicago/Turabian Style

Omersa, Neža, Marjetka Podobnik, and Gregor Anderluh. 2019. "Inhibition of Pore-Forming Proteins" Toxins 11, no. 9: 545.

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