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Review

Can Botulinum Toxin A Still Have a Role in Treatment of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Through Inhibition of Chronic Prostatic Inflammation?

1
College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan
2
Department of Urology, Cardinal Tien Hospital, New Taipei City 23148, Taiwan
3
Department of Life Science, College of Science, National Taiwan Normal University, Taipei 11677, Taiwan
4
Department of Urology, Buddhist Tzu Chi General Hospital, and Tzu Chi University, Hualien 97002, Taiwan
5
School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
*
Author to whom correspondence should be addressed.
Received: 28 August 2019 / Revised: 12 September 2019 / Accepted: 17 September 2019 / Published: 19 September 2019
Patients with benign prostatic hyperplasia (BPH) can exhibit various lower urinary tract symptoms (LUTS) owing to bladder outlet obstruction (BOO), prostatic inflammation, and bladder response to BOO. The pathogenesis of BPH involves an imbalance of internal hormones and chronic prostatic inflammation, possibly triggered by prostatic infection, autoimmune responses, neurogenic inflammation, oxidative stress, and autonomic dysfunction. Botulinum toxin A (BoNT-A) is well recognized for its ability to block acetylcholine release at the neuromuscular junction by cleaving synaptosomal-associated proteins. Although current large clinical trials have shown no clinical benefits of BoNT-A for the management of LUTS due to BPH, BoNT-A has demonstrated beneficial effects in certain subsets of BPH patients with LUTS, especially in males with concomitant chronic prostatitis/chronic pelvic pain syndrome and smaller prostate. We conducted a review of published literature in Pubmed, using Botulinum toxin, BPH, BOO, inflammation, LUTS, and prostatitis as the key words. This article reviewed the mechanisms of BPH pathogenesis and anti-inflammatory effects of BoNT-A. The results suggested that to achieve effectiveness, the treatment of BPH with BoNT-A should be tailored according to more detailed clinical information and reliable biomarkers. View Full-Text
Keywords: lower urinary tract symptoms; botulinum toxin; benign prostatic hyperplasia; prostatitis; inflammation lower urinary tract symptoms; botulinum toxin; benign prostatic hyperplasia; prostatitis; inflammation
MDPI and ACS Style

Chiang, B.-J.; Kuo, H.-C.; Liao, C.-H. Can Botulinum Toxin A Still Have a Role in Treatment of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Through Inhibition of Chronic Prostatic Inflammation? Toxins 2019, 11, 547. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins11090547

AMA Style

Chiang B-J, Kuo H-C, Liao C-H. Can Botulinum Toxin A Still Have a Role in Treatment of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Through Inhibition of Chronic Prostatic Inflammation? Toxins. 2019; 11(9):547. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins11090547

Chicago/Turabian Style

Chiang, Bing-Juin, Hann-Chorng Kuo, and Chun-Hou Liao. 2019. "Can Botulinum Toxin A Still Have a Role in Treatment of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Through Inhibition of Chronic Prostatic Inflammation?" Toxins 11, no. 9: 547. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins11090547

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