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Review

Use of Integrative Interactomics for Improvement of Farm Animal Health and Welfare: An Example with Fescue Toxicosis

Interdisciplinary Toxicology Program, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA
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Received: 8 July 2020 / Revised: 18 September 2020 / Accepted: 24 September 2020 / Published: 1 October 2020
(This article belongs to the Special Issue Global Impact of Ergot Alkaloids)
Rapid scientific advances are increasing our understanding of the way complex biological interactions integrate to maintain homeostatic balance and how seemingly small, localized perturbations can lead to systemic effects. The ‘omics movement, alongside increased throughput resulting from statistical and computational advances, has transformed our understanding of disease mechanisms and the multi-dimensional interaction between environmental stressors and host physiology through data integration into multi-dimensional analyses, i.e., integrative interactomics. This review focuses on the use of high-throughput technologies in farm animal research, including health- and toxicology-related papers. Although limited, we highlight recent animal agriculture-centered reports from the integrative multi-‘omics movement. We provide an example with fescue toxicosis, an economically costly disease affecting grazing livestock, and describe how integrative interactomics can be applied to a disease with a complex pathophysiology in the pursuit of novel treatment and management approaches. We outline how ‘omics techniques have been used thus far to understand fescue toxicosis pathophysiology, lay out a framework for the fescue toxicosis integrome, identify some challenges we foresee, and offer possible means for addressing these challenges. Finally, we briefly discuss how the example with fescue toxicosis could be used for other agriculturally important animal health and welfare problems. View Full-Text
Keywords: integrative interactomics; integrome; metabolomics; microbiome; tall fescue; Epichloë coenophiala; fescue toxicosis integrative interactomics; integrome; metabolomics; microbiome; tall fescue; Epichloë coenophiala; fescue toxicosis
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MDPI and ACS Style

Mote, R.S.; Filipov, N.M. Use of Integrative Interactomics for Improvement of Farm Animal Health and Welfare: An Example with Fescue Toxicosis. Toxins 2020, 12, 633. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12100633

AMA Style

Mote RS, Filipov NM. Use of Integrative Interactomics for Improvement of Farm Animal Health and Welfare: An Example with Fescue Toxicosis. Toxins. 2020; 12(10):633. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12100633

Chicago/Turabian Style

Mote, Ryan S., and Nikolay M. Filipov 2020. "Use of Integrative Interactomics for Improvement of Farm Animal Health and Welfare: An Example with Fescue Toxicosis" Toxins 12, no. 10: 633. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12100633

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