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Article

Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits

School of Veterinary Science, Massey University, Private Bag 11-222, Palmerston North 4442, New Zealand
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Author to whom correspondence should be addressed.
Received: 17 September 2020 / Revised: 12 October 2020 / Accepted: 29 October 2020 / Published: 2 November 2020
(This article belongs to the Special Issue Plant Toxins Affecting Animal Health and Production)
Cattle occasionally develop brassica-associated liver disease (BALD) and photosensitisation when grazing turnip or swede (Brassica spp.) forage crops. The liver toxin in these brassica varieties has yet to be discovered. Progoitrin is the dominant glucosinolate in incriminated crops. Apart from goitrin, progoitrin hydrolysis yields the nitrile, 1-cyano-2-hydroxy-3-butene (CHB), and the epithionitrile, 1-cyano-2-hydroxy-3,4-epithiobutane (CHEB). The two compounds were custom-synthesised. In a small pilot trial, New Zealand White rabbits were given either CHB or CHEB by gavage. Single doses of 0.75 mmol/kg of CHB or 0.25 mmol/kg of CHEB were subtoxic and elicited subclinical effects. Higher doses were severely hepatotoxic, causing periportal to massive hepatic necrosis associated with markedly elevated serum liver biomarkers often resulting in severe illness or death within 24 h. The possibility that one or both of these hepatotoxic nitriles causes BALD in cattle requires further investigation. View Full-Text
Keywords: brassica-associated liver disease; BALD; progoitrin; 1-cyano-2-hydroxy-3-butene; 1-cyano-2-hydroxy-3,4-epithiobutane; nitrile; toxicity; rabbits brassica-associated liver disease; BALD; progoitrin; 1-cyano-2-hydroxy-3-butene; 1-cyano-2-hydroxy-3,4-epithiobutane; nitrile; toxicity; rabbits
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MDPI and ACS Style

Collett, M.G.; Matthews, Z.M.; Parton, K.H. Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits. Toxins 2020, 12, 695. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110695

AMA Style

Collett MG, Matthews ZM, Parton KH. Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits. Toxins. 2020; 12(11):695. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110695

Chicago/Turabian Style

Collett, Mark G., Zoe M. Matthews, and Kathleen H. Parton 2020. "Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits" Toxins 12, no. 11: 695. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110695

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