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Article

Effects of Cassava Juice (Manihot esculenta Crantz) on Renal and Hepatic Function and Motor Impairments in Male Rats

1
Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa 91000, Veracruz, Mexico
2
Instituto de Ciencias Básicas, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico
3
Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico
*
Author to whom correspondence should be addressed.
Received: 30 August 2020 / Revised: 21 October 2020 / Accepted: 23 October 2020 / Published: 9 November 2020
Cassava (Manihot esculenta Crantz) is a plant that contains neurotoxins such as linamarin and lotaustraline. Its long-term consumption is associated with neuronal damage and contributes to the development of motor impairment in humans and rats. We investigated the effects of the consumption of cassava juice on renal and hepatic function and motor impairments in male rats. The rats received the vehicle, non-toxic and toxic doses of cassava juice, or linamarin as a pharmacological control, over 35 consecutive days. The effects were evaluated in an open field test, rotarod, and swim test. The toxic cassava dose and linamarin resulted in motor impairments in the rotarod and swim test from day 7 of treatment. The toxic cassava dose and linamarin increased the parameters that indicate renal and hepatic damage, with the exception of total protein and albumin levels. Behavioral variables that show motor incoordination (i.e., latency to fall in the rotarod) were negatively correlated with biochemical parameters of renal and kidney damage, whereas spin behavior was positively correlated. Our data indicate that chronic oral consumption of cassava juice caused renal and hepatic damage that was correlated with motor coordination impairment in rats, similarly to their principal neurotoxic compound, linamarin. View Full-Text
Keywords: cassava juice; renal function; hepatic function; motor incoordination; neurotoxic; hepatoxicity cassava juice; renal function; hepatic function; motor incoordination; neurotoxic; hepatoxicity
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MDPI and ACS Style

Rivadeneyra-Domínguez, E.; Pérez-Pérez, J.E.; Vázquez-Luna, A.; Díaz-Sobac, R.; Rodríguez-Landa, J.F. Effects of Cassava Juice (Manihot esculenta Crantz) on Renal and Hepatic Function and Motor Impairments in Male Rats. Toxins 2020, 12, 708. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110708

AMA Style

Rivadeneyra-Domínguez E, Pérez-Pérez JE, Vázquez-Luna A, Díaz-Sobac R, Rodríguez-Landa JF. Effects of Cassava Juice (Manihot esculenta Crantz) on Renal and Hepatic Function and Motor Impairments in Male Rats. Toxins. 2020; 12(11):708. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110708

Chicago/Turabian Style

Rivadeneyra-Domínguez, Eduardo; Pérez-Pérez, José E.; Vázquez-Luna, Alma; Díaz-Sobac, Rafael; Rodríguez-Landa, Juan F. 2020. "Effects of Cassava Juice (Manihot esculenta Crantz) on Renal and Hepatic Function and Motor Impairments in Male Rats" Toxins 12, no. 11: 708. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110708

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