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Biological Activity of Berberine—A Summary Update

Chair and Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodźki St., 20-093 Lublin, Poland
Department of Biochemistry, Institute of Medical Sciences, Medical College of Rzeszów University, 16c Rejtana St., 35-959 Rzeszów, Poland
Author to whom correspondence should be addressed.
Received: 2 November 2020 / Revised: 10 November 2020 / Accepted: 10 November 2020 / Published: 12 November 2020
(This article belongs to the Special Issue Identification and Functional Characterization of Plant Toxins)
Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity. Currently, berberine is receiving considerable interest due to its anticancer activity based on many biochemical pathways, especially its proapoptotic and anti-inflammatory activity. Therefore, the growing number of papers on berberine demands summarizing the knowledge and research trends. The efficacy of berberine in breast and colon cancers seems to be the most promising aspect. Many papers focus on novel therapeutic strategies based on new formulations or search for new active derivatives. The activity of berberine is very important as regards sensitization and support of anticancer therapy in combination with well-known but in some cases inefficient therapeutics. Currently, the compound is being assessed in many important clinical trials and is one of the most promising and intensively examined natural agents. View Full-Text
Keywords: berberine; anticancer; metabolic syndrome; apoptosis; clinical trials; bioavailability berberine; anticancer; metabolic syndrome; apoptosis; clinical trials; bioavailability
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MDPI and ACS Style

Och, A.; Podgórski, R.; Nowak, R. Biological Activity of Berberine—A Summary Update. Toxins 2020, 12, 713.

AMA Style

Och A, Podgórski R, Nowak R. Biological Activity of Berberine—A Summary Update. Toxins. 2020; 12(11):713.

Chicago/Turabian Style

Och, Anna, Rafał Podgórski, and Renata Nowak. 2020. "Biological Activity of Berberine—A Summary Update" Toxins 12, no. 11: 713.

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