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Article

Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation

1
Department of Pharmacology, Amiens University Medical Center, F-80000 Amiens, France
2
MP3CV Laboratory, EA7517, Jules Verne University of Picardie, F-80000 Amiens, France
3
Department of Rheumatology, Saint-Quentin Medical Center, F-02321 Amiens, France
4
RECIF, Amiens University Medical Center, F-80000 Amiens, France
5
Department of Rheumatology, Amiens University Medical Center, F-80000 Amiens, France
6
Department of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne Billancourt, F-92100 Paris, France
7
Centre for Research in Epidemiology and Population Health (CESP), INSERM UMRS 1018, Université Paris-Saclay, F-94807 Villejuif, France
8
Biochemistry Laboratory, Amiens University Medical Center, F-80000 Amiens, France
9
Department of Nephrology Internal Medicine Dialysis Transplantation, Amiens University Medical Center, F-80000 Amiens, France
*
Author to whom correspondence should be addressed.
Received: 9 October 2020 / Revised: 6 November 2020 / Accepted: 12 November 2020 / Published: 13 November 2020
Although uremic osteoporosis is a component of mineral and bone disorder in chronic kidney disease, uremic toxin (UT) concentrations in patients with end-stage kidney disease and bone mineral density (BMD) changes after kidney transplantation have not previously been described. We hypothesized that elevated UT concentrations at the time of transplantation could have a negative impact on bone during the early post-transplantation period. Hence, we sought to determine whether concentrations of UTs (trimethylamine-N-oxide, indoxylsulfate, p-cresylsulfate, p-cresylglucuronide, indole-3-acetic acid, hippuric acid, and 3-carboxy-4-methyl-5-propyl-furanpropionic acid) upon transplantation are predictive markers for (i) osteoporosis one month after transplantation, and (ii) a BMD decrease and the occurrence of fractures 12 and 24 months after kidney transplantation. Between 2012 and 2018, 310 kidney transplant recipients were included, and dual-energy X-ray absorptiometry was performed 1, 12, and 24 months after transplantation. The UT concentrations upon transplantation were determined by reverse-phase high-performance liquid chromatography. Indoxylsulfate concentrations upon transplantation were positively correlated with BMD one month after transplantation for the femoral neck but were not associated with osteoporosis status upon transplantation. Concentrations of the other UTs upon transplantation were not associated with osteoporosis or BMD one month after transplantation. None of the UT concentrations were associated with BMD changes and the occurrence of osteoporotic fractures 12 and 24 months after transplantation. Hence, UT concentrations at the time of kidney transplantation were not predictive markers of osteoporosis or fractures. View Full-Text
Keywords: uremic toxin; bone mineral density; fracture; kidney transplantation uremic toxin; bone mineral density; fracture; kidney transplantation
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MDPI and ACS Style

Batteux, B.; Bodeau, S.; André, C.; Hurtel-Lemaire, A.-S.; Gras-Champel, V.; Desailly-Henry, I.; Masmoudi, K.; Bennis, Y.; Massy, Z.A.; Kamel, S.; Choukroun, G.; Liabeuf, S. Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation. Toxins 2020, 12, 715. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110715

AMA Style

Batteux B, Bodeau S, André C, Hurtel-Lemaire A-S, Gras-Champel V, Desailly-Henry I, Masmoudi K, Bennis Y, Massy ZA, Kamel S, Choukroun G, Liabeuf S. Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation. Toxins. 2020; 12(11):715. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110715

Chicago/Turabian Style

Batteux, Benjamin, Sandra Bodeau, Camille André, Anne-Sophie Hurtel-Lemaire, Valérie Gras-Champel, Isabelle Desailly-Henry, Kamel Masmoudi, Youssef Bennis, Ziad A. Massy, Saïd Kamel, Gabriel Choukroun, and Sophie Liabeuf. 2020. "Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation" Toxins 12, no. 11: 715. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110715

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