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Review

Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins

Bruker Optik GmbH, Permoserstr, 15, 04318 Leipzig, Germany
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Author to whom correspondence should be addressed.
Received: 30 October 2020 / Revised: 12 November 2020 / Accepted: 16 November 2020 / Published: 20 November 2020
(This article belongs to the Special Issue Antibodies for Toxins: From Detection to Therapeutics)
Biological toxins are a heterogeneous group of high molecular as well as low molecular weight toxins produced by living organisms. Due to their physical and logistical properties, biological toxins are very attractive to terrorists for use in acts of bioterrorism. Therefore, among the group of biological toxins, several are categorized as security relevant, e.g., botulinum neurotoxins, staphylococcal enterotoxins, abrin, ricin or saxitoxin. Additionally, several security sensitive toxins also play a major role in natural food poisoning outbreaks. For a prompt response to a potential bioterrorist attack using biological toxins, first responders need reliable, easy-to-use and highly sensitive methodologies for on-site detection of the causative agent. Therefore, the aim of this review is to present on-site immunoassay platforms for multiplex detection of biological toxins. Furthermore, we introduce several commercially available detection technologies specialized for mobile or on-site identification of security sensitive toxins. View Full-Text
Keywords: security sensitive toxins; multiplex immunoassay platforms; on-site detection; optical biosensor; electrochemical biosensor; proteotoxins; low molecular weight toxins security sensitive toxins; multiplex immunoassay platforms; on-site detection; optical biosensor; electrochemical biosensor; proteotoxins; low molecular weight toxins
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MDPI and ACS Style

Pöhlmann, C.; Elßner, T. Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins. Toxins 2020, 12, 727. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110727

AMA Style

Pöhlmann C, Elßner T. Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins. Toxins. 2020; 12(11):727. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110727

Chicago/Turabian Style

Pöhlmann, Christopher; Elßner, Thomas. 2020. "Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins" Toxins 12, no. 11: 727. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110727

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