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Review

Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori

School of Pharmacy, The Chinese University of Hong Kong, Hong Kong 999077, China
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Author to whom correspondence should be addressed.
Received: 10 October 2020 / Revised: 18 November 2020 / Accepted: 19 November 2020 / Published: 21 November 2020
(This article belongs to the Special Issue Toxicity of Plant Derived Substances)
Radix Polygoni Multiflori (RPM), a traditional Chinese medicine, has been used as a tonic and an anti-aging remedy for centuries. However, its safe and effective application in clinical practice could be hindered by its liver injury potential and lack of investigations on its hepatotoxicity mechanism. Our current review aims to provide a comprehensive overview and a critical assessment of the absorption, distribution, metabolism, excretion of RPM, and their relationships with its induced liver injury. Based on the well-reported intrinsic liver toxicity of emodin, one of the major components in RPM, it is concluded that its plasma and liver concentrations could attribute to RPM induced liver injury via metabolic enzymes alteration, hepatocyte apoptosis, bile acids homeostasis disruption, and inflammatory damage. Co-administered 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in RPM and other drugs/herbs could further aggravate the hepatotoxicity of emodin via enhancing its absorption and inhibiting its metabolism. To ensure the safe clinical use of RPM, a better understanding of the toxicokinetics and effect of its co-occurring components or other co-administered drugs/herbs on the pharmacokinetics of emodin is warranted. View Full-Text
Keywords: radix polygoni multiflori; herb induced liver injury; pharmacokinetics; mechanism; herb–drug/herb interaction radix polygoni multiflori; herb induced liver injury; pharmacokinetics; mechanism; herb–drug/herb interaction
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MDPI and ACS Style

Li, D.; Yang, M.; Zuo, Z. Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori. Toxins 2020, 12, 729. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110729

AMA Style

Li D, Yang M, Zuo Z. Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori. Toxins. 2020; 12(11):729. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110729

Chicago/Turabian Style

Li, Dan, Mengbi Yang, and Zhong Zuo. 2020. "Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori" Toxins 12, no. 11: 729. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12110729

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