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Review

Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function

Department of Biology, Laurentian University, 935 Ramsey Lake Rd., Sudbury, ON P3E 2C6, Canada
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Author to whom correspondence should be addressed.
Received: 1 October 2020 / Revised: 24 November 2020 / Accepted: 26 November 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Escherichia coli Toxins and Intestinal Diseases)
Enterotoxigenic Escherichia coli (ETEC) produces the heat-stable enterotoxin b (STb), which is responsible for secretory diarrhea in humans and animals. This toxin is secreted within the intestinal lumen of animals and humans following ETEC colonization, becoming active on enterocytes and altering fluid homeostasis. Several studies have outlined the nature of this toxin and its effects on gut health and the integrity of the intestinal epithelium. This review summarizes the mechanisms of how STb alters the gastrointestinal tract. These include the manipulation of mucosal tight junction protein integrity, the formation of enterocyte cellular pores and toxin internalization and the stimulation of programmed cell death. We conclude with insights into the potential link between STb intoxication and altered gut hormone regulation, and downstream physiology. View Full-Text
Keywords: Escherichia coli; ETEC; enterotoxigenic; enterotoxins; heat-stable; gastrointestinal; internalization; tight junction; apoptosis; hormones Escherichia coli; ETEC; enterotoxigenic; enterotoxins; heat-stable; gastrointestinal; internalization; tight junction; apoptosis; hormones
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MDPI and ACS Style

Butt, S.; Saleh, M.; Gagnon, J. Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function. Toxins 2020, 12, 760. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12120760

AMA Style

Butt S, Saleh M, Gagnon J. Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function. Toxins. 2020; 12(12):760. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12120760

Chicago/Turabian Style

Butt, Shahnawaz, Mazen Saleh, and Jeffrey Gagnon. 2020. "Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function" Toxins 12, no. 12: 760. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12120760

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