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Article

Adverse Reactions after Administration of Antivenom in Korea

1
Department of Emergency Medicine, College of Medicine, Hanyang University Hospital, Hanyang University, 04763 Seoul, Korea
2
Department of Emergency Medicine, College of Medicine, Hanyang University Guri Hospital, Hanyang University, 11923 Guri, Korea
*
Authors to whom correspondence should be addressed.
Received: 30 June 2020 / Revised: 2 August 2020 / Accepted: 4 August 2020 / Published: 6 August 2020
(This article belongs to the Special Issue Novel Strategies for the Diagnosis and Treatment of Snakebites)
Kovax® antivenom is the main treatment for toxins produced by the Gloydius species. However, research on adverse reactions after Kovax® antivenom administration is scarce. We aimed to identify the incidence and characteristics of adverse reactions after Kovax® antivenom administration. We conducted a retrospective review of the medical records of snakebite patients in Korea between January 2008 and September 2019. We identified the frequency, characteristics, and treatments of adverse reactions to Kovax® antivenom. There were 150 patients with snakebites, of whom 121 (80.7%) patients received Kovax® antivenom. Adverse reactions occurred in five patients (4.1%). Acute adverse reactions within 24 h of antivenom administration occurred in two patients (1.7%). The symptoms of patients with acute adverse reactions were nausea, diaphoresis, dizziness, and hypotension. Delayed adverse reactions that occurred 24 h after antivenom administration were reported in three patients (2.5%). One patient had a skin rash after 10 days, and two patients had fever 37 and 48 h after antivenom use. In conclusion, most patients were managed safely after Kovax® antivenom, and the incidence of adverse reactions was low. Severe adverse reactions occurred in a small percentage of patients, and there were no deaths. View Full-Text
Keywords: snake venom; antivenom; adverse reaction; snakebite snake venom; antivenom; adverse reaction; snakebite
MDPI and ACS Style

Shim, J.S.; Kang, H.; Cho, Y.; Shin, H.; Lee, H. Adverse Reactions after Administration of Antivenom in Korea. Toxins 2020, 12, 507. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12080507

AMA Style

Shim JS, Kang H, Cho Y, Shin H, Lee H. Adverse Reactions after Administration of Antivenom in Korea. Toxins. 2020; 12(8):507. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12080507

Chicago/Turabian Style

Shim, Jin S.; Kang, Hyunggoo; Cho, Yongil; Shin, Hyungoo; Lee, Heekyung. 2020. "Adverse Reactions after Administration of Antivenom in Korea" Toxins 12, no. 8: 507. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12080507

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