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Article

First Detection of Tetrodotoxin in Bivalves and Gastropods from the French Mainland Coasts

1
Université Paris-Est, ANSES, Laboratory for Food Safety, F-94701 Maisons-Alfort, France
2
ANSES, Risk Assessment Directorate, F-94701 Maisons-Alfort, France
*
Author to whom correspondence should be addressed.
Received: 13 August 2020 / Revised: 9 September 2020 / Accepted: 11 September 2020 / Published: 16 September 2020
In 2015, tetrodotoxins (TTXs) were considered a potential threat in Europe since several studies had shown the presence of these toxins in European bivalve molluscs. In this study, we investigated the occurrence of TTXs in 127 bivalve samples (mussels and oysters) and in 66 gastropod samples (whelks) collected all along the French mainland coasts in 2017 and 2018. Analyses were carried out after optimization and in-house validation of a performing hydrophilic interaction liquid chromatography associated with tandem mass spectrometry (HILIC-MS/MS) method. The concentration set by European Food Safety Authority (EFSA) not expected to result in adverse effects (44 µg TTX equivalent/kg) was never exceeded, but TTX was detected in three mussel samples and one whelk sample (1.7–11.2 µg/kg). The tissue distribution of TTX in this whelk sample showed higher concentrations in the digestive gland, stomach and gonads (7.4 µg TTX/kg) than in the rest of the whelk tissues (below the limit of detection of 1.7 µg TTX/kg). This is the first study to report the detection of TTX in French molluscs. View Full-Text
Keywords: tetrodotoxins (TTXs); bivalve molluscs; gastropods; hydrophilic interaction liquid chromatography associated with tandem mass spectrometry (HILIC-MS/MS); tetrodotoxin shellfish poisoning (TSP) tetrodotoxins (TTXs); bivalve molluscs; gastropods; hydrophilic interaction liquid chromatography associated with tandem mass spectrometry (HILIC-MS/MS); tetrodotoxin shellfish poisoning (TSP)
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MDPI and ACS Style

Hort, V.; Arnich, N.; Guérin, T.; Lavison-Bompard, G.; Nicolas, M. First Detection of Tetrodotoxin in Bivalves and Gastropods from the French Mainland Coasts. Toxins 2020, 12, 599. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12090599

AMA Style

Hort V, Arnich N, Guérin T, Lavison-Bompard G, Nicolas M. First Detection of Tetrodotoxin in Bivalves and Gastropods from the French Mainland Coasts. Toxins. 2020; 12(9):599. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12090599

Chicago/Turabian Style

Hort, Vincent, Nathalie Arnich, Thierry Guérin, Gwenaëlle Lavison-Bompard, and Marina Nicolas. 2020. "First Detection of Tetrodotoxin in Bivalves and Gastropods from the French Mainland Coasts" Toxins 12, no. 9: 599. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins12090599

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