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Review

Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism

1
Department of Dermatology, Sungkyunkwan University School of Medicine, Seoul 06355, Korea
2
Leaders Aesthetic Laser & Cosmetic Surgery Center, Seoul 06014, Korea
3
Department of Anatomy, Chungbuk National University School of Medicine, Cheongju 28644, Korea
*
Author to whom correspondence should be addressed.
Received: 31 October 2021 / Revised: 15 November 2021 / Accepted: 17 November 2021 / Published: 19 November 2021
(This article belongs to the Special Issue Botulinum Toxins in Clinical Practice)
Intradermal injection of botulinum neurotoxin is a frequently performed procedure in aesthetic dermatology to improve facial skin tone, texture, fine wrinkles, and enlarged pores. In practice, botulinum neurotoxin type A is also used to reduce skin oiliness of the face. There is increasing evidence that acetylcholine plays specific roles in sebum production, suggesting that botulinum neurotoxin type A may reduce sebum production by interfering with cholinergic transmission between sebaceous glands and autonomic nerve terminals. Botulinum neurotoxins can also inhibit several pathogenetic components of acne development, suggesting that botulinum neurotoxins can be used as a safe and effective treatment modality for acne and other skin disorders related to overactivity of sebaceous glands. This review aims to explore the current evidence behind the treatment of facial seborrhea and acne with botulinum neurotoxin type A. View Full-Text
Keywords: acetylcholine; acne vulgaris; botulinum toxins; cholinergic receptors; non-neuronal cholinergic system; oily skin; sebaceous glands; seborrhea; sebum acetylcholine; acne vulgaris; botulinum toxins; cholinergic receptors; non-neuronal cholinergic system; oily skin; sebaceous glands; seborrhea; sebum
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MDPI and ACS Style

Rho, N.-K.; Gil, Y.-C. Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism. Toxins 2021, 13, 817. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13110817

AMA Style

Rho N-K, Gil Y-C. Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism. Toxins. 2021; 13(11):817. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13110817

Chicago/Turabian Style

Rho, Nark-Kyoung, and Young-Chun Gil. 2021. "Botulinum Neurotoxin Type A in the Treatment of Facial Seborrhea and Acne: Evidence and a Proposed Mechanism" Toxins 13, no. 11: 817. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13110817

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