Next Article in Journal
Occurrence of Fusarium Mycotoxins and Their Modified Forms in Forage Maize Cultivars
Next Article in Special Issue
The Occurrence of Mycotoxins in Raw Materials and Fish Feeds in Europe and the Potential Effects of Deoxynivalenol (DON) on the Health and Growth of Farmed Fish Species—A Review
Previous Article in Journal
Diet Diversity in Carnivorous Terebrid Snails Is Tied to the Presence and Absence of a Venom Gland
Previous Article in Special Issue
Co-Occurrence and Levels of Mycotoxins in Fish Feeds in Kenya
Article

Individual and Combined Effects of Aflatoxin B1 and Sterigmatocystin on Lipid Peroxidation and Glutathione Redox System of Common Carp Liver

1
Department of Nutrition, Szent István University, H-2100 Gödöllő, Hungary
2
Mycotoxins in the Food Chain Research Group, Hungarian Academy of Sciences, Kaposvár Campus, Szent István University, H-7400 Kaposvár, Hungary
*
Author to whom correspondence should be addressed.
Received: 23 December 2020 / Revised: 20 January 2021 / Accepted: 29 January 2021 / Published: 2 February 2021
(This article belongs to the Special Issue Mycotoxins in Feeds and Their Effects on Fish)
The purpose of the study was to evaluate the short-term effects of aflatoxin B1 (AFB1 100 µg/kg feed) and sterigmatocystin (STC 1000 μg/kg feed) exposure individually and in combination (100 μg AFB1 + 1000 μg STC/kg feed) on the parameters of lipid peroxidation and glutathione redox system both in biochemical and gene expression levels in one-year-old common carp. Lipid peroxidation parameters were slightly affected, as significant differences were observed only in conjugated diene and triene concentrations. Reduced glutathione content decreased more markedly by STC than AFB1 or AFB1+STC, but glutathione peroxidase activity did not change. Expression of gpx4a, gpx4b, gss, and gsr genes was down-regulated due to STC compared to AFB1 or AFB1+STC, while an induction was found as effect of AFB1+STC in the case of gpx4a, but down-regulation for gpx4b as compared to AFB1. Expression of the glutathione biosynthesis regulatory gene, gss, was higher, but glutathione recycling enzyme encoding gene, gsr, was lower as an effect of AFB1+STC compared to AFB1. These results are supported by the changes in the expression of transcription factors encoding genes, nrf2, and keap1. The results revealed that individual effects of AFB1 and STC on different parameters are synergistic or antagonistic in multi-toxin treatment. View Full-Text
Keywords: sterigmatocystin; aflatoxin B1; oxidative stress; glutathione redox system; gene expression; common carp sterigmatocystin; aflatoxin B1; oxidative stress; glutathione redox system; gene expression; common carp
MDPI and ACS Style

Kövesi, B.; Kulcsár, S.; Ancsin, Z.; Zándoki, E.; Erdélyi, M.; Mézes, M.; Balogh, K. Individual and Combined Effects of Aflatoxin B1 and Sterigmatocystin on Lipid Peroxidation and Glutathione Redox System of Common Carp Liver. Toxins 2021, 13, 109. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13020109

AMA Style

Kövesi B, Kulcsár S, Ancsin Z, Zándoki E, Erdélyi M, Mézes M, Balogh K. Individual and Combined Effects of Aflatoxin B1 and Sterigmatocystin on Lipid Peroxidation and Glutathione Redox System of Common Carp Liver. Toxins. 2021; 13(2):109. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13020109

Chicago/Turabian Style

Kövesi, Benjamin, Szabina Kulcsár, Zsolt Ancsin, Erika Zándoki, Márta Erdélyi, Miklós Mézes, and Krisztián Balogh. 2021. "Individual and Combined Effects of Aflatoxin B1 and Sterigmatocystin on Lipid Peroxidation and Glutathione Redox System of Common Carp Liver" Toxins 13, no. 2: 109. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13020109

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop