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Efficient Aflatoxin B1 Sequestration by Yeast Cell Wall Extract and Hydrated Sodium Calcium Aluminosilicate Evaluated Using a Multimodal In-Vitro and Ex-Vivo Methodology
Article

Saccharomyces cerevisiae Cell Wall-Based Adsorbent Reduces Aflatoxin B1 Absorption in Rats

1
Chemistry and Toxicology Division, Center for Animal Nutrigenomic and Applied Animal Nutrition, Alltech Inc., 3031, Nicholasville, KY 40356, USA
2
Alimetrics Ltd., Koskelontie 19B, 02920 Espoo, Finland
3
Alltech Ireland, Sarney, Summerhill Road, A86 X006 Dunboyne, Ireland
4
Alltech SARL (France), Rue Charles Amand, 14500 Vire, France
*
Author to whom correspondence should be addressed.
Received: 22 February 2021 / Revised: 11 March 2021 / Accepted: 12 March 2021 / Published: 13 March 2021
(This article belongs to the Collection Aflatoxins)
Mycotoxins are naturally occurring toxins that can affect livestock health and performance upon consumption of contaminated feedstuffs. To mitigate the negative effects of mycotoxins, sequestering agents, adsorbents, or binders can be included to feed to interact with toxins, aiding their passage through the gastrointestinal tract (GI) and reducing their bioavailability. The parietal cell wall components of Saccharomyces cerevisiae have been found to interact in vitro with mycotoxins, such as, but not limited to, aflatoxin B1 (AFB1), and to improve animal performance when added to contaminated diets in vivo. The present study aimed to examine the pharmacokinetics of the absorption of radiolabeled AFB1 in rats in the presence of a yeast cell wall-based adsorbent (YCW) compared with that in the presence of the clay-based binder hydrated sodium calcium aluminosilicate (HSCAS). The results of the initial pharmacokinetic analysis showed that the absorption process across the GI tract was relatively slow, occurring over a matter of hours rather than minutes. The inclusion of mycotoxin binders increased the recovery of radiolabeled AFB1 in the small intestine, cecum, and colon at 5 and 10 h, revealing that they prevented AFB1 absorption compared with a control diet. Additionally, the accumulation of radiolabeled AFB1 was more significant in the blood plasma, kidney, and liver of animals fed the control diet, again showing the ability of the binders to reduce the assimilation of AFB1 into the body. The results showed the potential of YCW in reducing the absorption of AFB1 in vivo, and in protecting against the damaging effects of AFB1 contamination. View Full-Text
Keywords: mycotoxins; aflatoxin B1; yeast cell wall; binder; animal health; absorption; adsorption mycotoxins; aflatoxin B1; yeast cell wall; binder; animal health; absorption; adsorption
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MDPI and ACS Style

Yiannikouris, A.; Apajalahti, J.; Siikanen, O.; Dillon, G.P.; Moran, C.A. Saccharomyces cerevisiae Cell Wall-Based Adsorbent Reduces Aflatoxin B1 Absorption in Rats. Toxins 2021, 13, 209. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13030209

AMA Style

Yiannikouris A, Apajalahti J, Siikanen O, Dillon GP, Moran CA. Saccharomyces cerevisiae Cell Wall-Based Adsorbent Reduces Aflatoxin B1 Absorption in Rats. Toxins. 2021; 13(3):209. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13030209

Chicago/Turabian Style

Yiannikouris, Alexandros, Juha Apajalahti, Osmo Siikanen, Gerald P. Dillon, and Colm A. Moran 2021. "Saccharomyces cerevisiae Cell Wall-Based Adsorbent Reduces Aflatoxin B1 Absorption in Rats" Toxins 13, no. 3: 209. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13030209

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