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Ageritin from Pioppino Mushroom: The Prototype of Ribotoxin-Like Proteins, a Novel Family of Specific Ribonucleases in Edible Mushrooms

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), University of Campania ‘Luigi Vanvitelli’, Via Vivaldi 43, 81100-Caserta, Italy
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Received: 24 February 2021 / Revised: 31 March 2021 / Accepted: 5 April 2021 / Published: 7 April 2021
Ageritin is a specific ribonuclease, extracted from the edible mushroom Cyclocybe aegerita (synonym Agrocybe aegerita), which cleaves a single phosphodiester bond located within the universally conserved alpha-sarcin loop (SRL) of 23–28S rRNAs. This cleavage leads to the inhibition of protein biosynthesis, followed by cellular death through apoptosis. The structural and enzymatic properties show that Ageritin is the prototype of a novel specific ribonucleases family named ‘ribotoxin-like proteins’, recently found in fruiting bodies of other edible basidiomycetes mushrooms (e.g., Ostreatin from Pleurotus ostreatus, Edulitins from Boletus edulis, and Gambositin from Calocybe gambosa). Although the putative role of this toxin, present in high amount in fruiting body (>2.5 mg per 100 g) of C. aegerita, is unknown, its antifungal and insecticidal actions strongly support a role in defense mechanisms. Thus, in this review, we focus on structural, biological, antipathogenic, and enzymatic characteristics of this ribotoxin-like protein. We also highlight its biological relevance and potential biotechnological applications in agriculture as a bio-pesticide and in biomedicine as a therapeutic and diagnostic agent. View Full-Text
Keywords: Agrocybe aegerita; Cyclocybe aegerita; antiviral activity; antifungal activity; endonuclease activity; cytotoxicity; protein structure function Agrocybe aegerita; Cyclocybe aegerita; antiviral activity; antifungal activity; endonuclease activity; cytotoxicity; protein structure function
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MDPI and ACS Style

Ragucci, S.; Landi, N.; Russo, R.; Valletta, M.; Pedone, P.V.; Chambery, A.; Di Maro, A. Ageritin from Pioppino Mushroom: The Prototype of Ribotoxin-Like Proteins, a Novel Family of Specific Ribonucleases in Edible Mushrooms. Toxins 2021, 13, 263. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13040263

AMA Style

Ragucci S, Landi N, Russo R, Valletta M, Pedone PV, Chambery A, Di Maro A. Ageritin from Pioppino Mushroom: The Prototype of Ribotoxin-Like Proteins, a Novel Family of Specific Ribonucleases in Edible Mushrooms. Toxins. 2021; 13(4):263. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13040263

Chicago/Turabian Style

Ragucci, Sara, Nicola Landi, Rosita Russo, Mariangela Valletta, Paolo V. Pedone, Angela Chambery, and Antimo Di Maro. 2021. "Ageritin from Pioppino Mushroom: The Prototype of Ribotoxin-Like Proteins, a Novel Family of Specific Ribonucleases in Edible Mushrooms" Toxins 13, no. 4: 263. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13040263

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