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Article

Botulinum Toxin Type-A (Botulax®) Treatment in Patients with Intractable Chronic Occipital Neuralgia: A Pilot Study

1
Department of Neurology, International St. Mary’s Hospital, College of Medicine, Catholic Kwandong University, 25, 100 Beon-gil, Simgok-ro, Seo-gu, Incheon 22711, Korea
2
Department of Medical Business Administration, Daegu Haany University, 201, Daegudae-ro, Gyeongsan-si 38610, Korea
3
Department of Orofacial Pain and Oral Medicine, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
Received: 6 April 2021 / Revised: 26 April 2021 / Accepted: 30 April 2021 / Published: 4 May 2021
(This article belongs to the Special Issue Application of Botulinum Toxin in Clinical Medicine)
Intractable chronic occipital neuralgia (ON) is an uncommon type of headache often experienced by patients in outpatient neurological clinics. Among patients unresponsive to oral neuralgia medications, needling or injections with several drugs were suggested alternatives for treating chronic ON. This study aimed to determine the effectiveness and safety of botulinum toxin type-A (BTX-A) injection treatments, where eight patients with unilateral chronic ON received BTX-A injections at the pain sites. The pain relief effect was observed 2 weeks after receiving the injections, gradually showing improvements up to 12 weeks after injection. There were no adverse events or changes from baseline in serologic studies and vital signs in any of the participants. The treatment’s pain-relieving effects were confirmed through regular, 12-week follow-ups, confirming the safety and effectiveness of BTX-A on chronic ON and suggesting that this method is an effective, novel alternative option for chronic ON treatment. View Full-Text
Keywords: chronic occipital neuralgia; greater occipital nerve; botulinum toxin injection chronic occipital neuralgia; greater occipital nerve; botulinum toxin injection
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MDPI and ACS Style

Kim, H.; Jang, B.; Kim, S.-T. Botulinum Toxin Type-A (Botulax®) Treatment in Patients with Intractable Chronic Occipital Neuralgia: A Pilot Study. Toxins 2021, 13, 332. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13050332

AMA Style

Kim H, Jang B, Kim S-T. Botulinum Toxin Type-A (Botulax®) Treatment in Patients with Intractable Chronic Occipital Neuralgia: A Pilot Study. Toxins. 2021; 13(5):332. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13050332

Chicago/Turabian Style

Kim, Hyeyun, Bongjin Jang, and Seong-Taek Kim. 2021. "Botulinum Toxin Type-A (Botulax®) Treatment in Patients with Intractable Chronic Occipital Neuralgia: A Pilot Study" Toxins 13, no. 5: 332. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13050332

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