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Article

Adsorbents Reduce Aflatoxin M1 Residue in Milk of Healthy Dairy Cow Exposed to Moderate Level Aflatoxin B1 in Diet and Its Exposure Risk for Humans

1
College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China
2
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
3
College of Animal Science, Hebei Agricultural University, Baoding 071000, China
*
Author to whom correspondence should be addressed.
Received: 1 August 2021 / Revised: 6 September 2021 / Accepted: 13 September 2021 / Published: 17 September 2021
(This article belongs to the Special Issue Remediation Strategies for Mycotoxin in Animal Feed)
This study investigated the effect of moderate risk level (8 µg/kg) AFB1 in diet supplemented with or without adsorbents on lactation performance, serum parameters, milk AFM1 content of healthy lactating cows and the AFM1 residue exposure risk in different human age groups. Forty late healthy lactating Holstein cows (270 ± 22 d in milk; daily milk yield 21 ± 3.1 kg/d) were randomly assigned to four treatments: control diet without AFB1 and adsorbents (CON), CON with 8 μg/kg AFB1 (dry matter basis, AF), AF + 15 g/d adsorbent 1 (AD1), AF + 15 g/d adsorbent 2 (AD2). The experiment lasted for 19 days, including an AFB1-challenge phase (day 1 to 14) and an AFB1-withdraw phase (day 15 to 19). Results showed that both AFB1 and adsorbents treatments had no significant effects on the DMI, milk yield, 3.5% FCM yield, milk components and serum parameters. Compared with the AF, AD1 and AD2 had significantly lower milk AFM1 concentrations (93 ng/L vs. 46 ng/L vs. 51 ng/L) and transfer rates of dietary AFB1 into milk AFM1 (1.16% vs. 0.57% vs. 0.63%) (p < 0.05). Children aged 2–4 years old had the highest exposure risk to AFM1 in milk in AF, with an EDI of 1.02 ng/kg bw/day and a HI of 5.11 (HI > 1 indicates a potential risk for liver cancer). Both AD1 and AD2 had obviously reductions in EDI and HI for all population groups, whereas, the EDI (≥0.25 ng/kg bw/day) and HI (≥1.23) of children aged 2–11 years old were still higher than the suggested tolerable daily intake (TDI) of 0.20 ng/kg bw/day and 1.00 (HI). In conclusion, moderate risk level AFB1 in the diet of healthy lactating cows could cause a public health hazard and adding adsorbents in the dairy diet is an effective measure to remit AFM1 residue in milk and its exposure risk for humans. View Full-Text
Keywords: aflatoxin B1; moderate risk level; adsorbents; aflatoxin M1; transfer rate; dairy cows; exposure risk assessment aflatoxin B1; moderate risk level; adsorbents; aflatoxin M1; transfer rate; dairy cows; exposure risk assessment
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MDPI and ACS Style

Cha, M.; Wang, E.; Hao, Y.; Ji, S.; Huang, S.; Zhao, L.; Wang, W.; Shao, W.; Wang, Y.; Li, S. Adsorbents Reduce Aflatoxin M1 Residue in Milk of Healthy Dairy Cow Exposed to Moderate Level Aflatoxin B1 in Diet and Its Exposure Risk for Humans. Toxins 2021, 13, 665. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13090665

AMA Style

Cha M, Wang E, Hao Y, Ji S, Huang S, Zhao L, Wang W, Shao W, Wang Y, Li S. Adsorbents Reduce Aflatoxin M1 Residue in Milk of Healthy Dairy Cow Exposed to Moderate Level Aflatoxin B1 in Diet and Its Exposure Risk for Humans. Toxins. 2021; 13(9):665. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13090665

Chicago/Turabian Style

Cha, Manqian, Erdan Wang, Yangyi Hao, Shoukun Ji, Shuai Huang, Lihong Zhao, Wei Wang, Wei Shao, Yajing Wang, and Shengli Li. 2021. "Adsorbents Reduce Aflatoxin M1 Residue in Milk of Healthy Dairy Cow Exposed to Moderate Level Aflatoxin B1 in Diet and Its Exposure Risk for Humans" Toxins 13, no. 9: 665. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13090665

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