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Review

Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia

James P.Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box 704, Rochester, NY 14642, USA
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Author to whom correspondence should be addressed.
Co-first author.
Received: 1 May 2018 / Revised: 30 May 2018 / Accepted: 1 June 2018 / Published: 4 June 2018
(This article belongs to the Special Issue Treatment of Older Adults with Acute Myeloid Leukemia)
Acute myeloid leukemia (AML) is a disease that affects adults aged 65 years and above, and survival in this population is poor. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for these patients but is underutilized due to frequent comorbidities and perceived higher risk of treatment-related mortality and non-relapse mortality. Increasing data supports the utility of allo-HCT in fit older patients after intensive chemotherapy resulting in improvement of outcomes. With the development of reduced intensity and non-myeloablative conditioning regimens that are associated with lower rates of treatment-related toxicity and mortality, this has allowed more older patients with AML to receive allo-HCT. In this review, we provide some guidance on appropriate selection of older patients as transplant candidates, benefits and risks associated with allo-HCT, conditioning regimen choice, and stem cell transplant sources as they relate to the conduct of stem cell transplantation in older patients. View Full-Text
Keywords: allogeneic stem cell transplantation; older adults; acute myeloid leukemia allogeneic stem cell transplantation; older adults; acute myeloid leukemia
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MDPI and ACS Style

Lipof, J.J.; Loh, K.P.; O’Dwyer, K.; Liesveld, J.L. Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia. Cancers 2018, 10, 179. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers10060179

AMA Style

Lipof JJ, Loh KP, O’Dwyer K, Liesveld JL. Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia. Cancers. 2018; 10(6):179. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers10060179

Chicago/Turabian Style

Lipof, Jodi J., Kah P. Loh, Kristen O’Dwyer, and Jane L. Liesveld 2018. "Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia" Cancers 10, no. 6: 179. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers10060179

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